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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0004153,
umls-concept:C0019576,
umls-concept:C0021655,
umls-concept:C0042874,
umls-concept:C0043157,
umls-concept:C0085756,
umls-concept:C0086418,
umls-concept:C0220938,
umls-concept:C0920563,
umls-concept:C1425233,
umls-concept:C1512806,
umls-concept:C1518424,
umls-concept:C2603343,
umls-concept:C2817684
|
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-11-20
|
| pubmed:abstractText |
Elevated fasting insulin concentrations and insulin resistance have been associated with non-insulin-dependent diabetes mellitus (NIDDM), obesity, atherosclerosis, and hypertension. Vitamin E supplementation in persons with and without NIDDM may be related to greater insulin sensitivity (SI). The cross-sectional associations of the intake of vitamins E and C with SI and insulin concentrations were evaluated among African American, Hispanic, and non-Hispanic white men and women with a wide spectrum of glucose tolerance included in the Insulin Resistance and Atherosclerosis Study (IRAS) (n = 1151). Insulin sensitivity was measured by minimal model analysis of a 12-sample, insulin-modified, frequently sampled intravenous glucose tolerance test. Nutrient intake (including vitamin supplement use) was assessed with a food-frequency questionnaire modified to include foods consumed by the three ethnic groups. Linear-regression models were used, including rank of SI and the log of fasting insulin as the outcome variables. Pearson correlation coefficients for vitamins E and C in relation to rank SI were r = 0.07 (P = 0.01) and r = 0.07 (P = 0.02), respectively. After adjustment for total energy and BMI these associations were no longer statistically significant and did not differ between ethnic groups. Results were similar when vitamins E and C were combined in categories of low and high antioxidant intake. Models replicated with log of fasting insulin as the outcome variable also did not produce significant associations with vitamins E or C. Thus, these cross-sectional analyses do not support the hypothesis of improved SI with increased intake of vitamins E and C.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0002-9165
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
66
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1224-31
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9356542-Adult,
pubmed-meshheading:9356542-African Continental Ancestry Group,
pubmed-meshheading:9356542-Aged,
pubmed-meshheading:9356542-Ascorbic Acid,
pubmed-meshheading:9356542-Blood Glucose,
pubmed-meshheading:9356542-Cross-Sectional Studies,
pubmed-meshheading:9356542-Diabetes Mellitus, Type 2,
pubmed-meshheading:9356542-Diet,
pubmed-meshheading:9356542-European Continental Ancestry Group,
pubmed-meshheading:9356542-Female,
pubmed-meshheading:9356542-Humans,
pubmed-meshheading:9356542-Insulin Resistance,
pubmed-meshheading:9356542-Linear Models,
pubmed-meshheading:9356542-Male,
pubmed-meshheading:9356542-Mexican Americans,
pubmed-meshheading:9356542-Middle Aged,
pubmed-meshheading:9356542-Risk Factors,
pubmed-meshheading:9356542-United States,
pubmed-meshheading:9356542-Vitamin E
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Insulin sensitivity and intake of vitamins E and C in African American, Hispanic, and non-Hispanic white men and women: the Insulin Resistance and Atherosclerosis Study (IRAS).
|
| pubmed:affiliation |
Department of Public Health Sciences, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Multicenter Study
|