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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-11-21
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pubmed:abstractText |
The immunoglobulin alpha (Ig alpha)/Ig beta heterodimer was detected on the surface of mu-negative proB cell lines in association with calnexin. The cross-linking of Ig beta on proB cells freshly isolated from bone marrow of recombination activating gene (RAG)-2-deficient mice induced a rapid and transient tyrosine-phosphorylation of Ig alpha as well as an array of intracellular proteins including Syk, PI3-kinase, Vav, and SLP-76. It also elicited the phosphorylation and activation of a MAP kinase ERK but not JNK/SAPK or p38. When RAG-2-deficient mice were treated with anti-Ig beta monoclonal antibody, developmentally arrested proB cells were induced to differentiate to the small preB cell stage as observed when the mu transgene was expressed in RAG-2-deficient mice. Thus, the cross-linking of Ig beta on proB cells appears to elicit differentiation signals analogous to those delivered by the preB cell receptor in normal B cell development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD79,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Calnexin,
http://linkedlifedata.com/resource/pubmed/chemical/Cd79a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cd79b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin mu-Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Rag2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/V(D)J recombination activating...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
559-70
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9354476-Animals,
pubmed-meshheading:9354476-Antigens, CD,
pubmed-meshheading:9354476-Antigens, CD79,
pubmed-meshheading:9354476-B-Lymphocytes,
pubmed-meshheading:9354476-Bone Marrow Cells,
pubmed-meshheading:9354476-Calcium-Binding Proteins,
pubmed-meshheading:9354476-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9354476-Calnexin,
pubmed-meshheading:9354476-Cell Differentiation,
pubmed-meshheading:9354476-Cell Membrane,
pubmed-meshheading:9354476-DNA-Binding Proteins,
pubmed-meshheading:9354476-Dimerization,
pubmed-meshheading:9354476-Immunoglobulin mu-Chains,
pubmed-meshheading:9354476-Leukopoiesis,
pubmed-meshheading:9354476-Mice,
pubmed-meshheading:9354476-Mice, Knockout,
pubmed-meshheading:9354476-Mice, Transgenic,
pubmed-meshheading:9354476-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:9354476-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9354476-Phosphotyrosine,
pubmed-meshheading:9354476-Protein Kinases,
pubmed-meshheading:9354476-Receptor Aggregation,
pubmed-meshheading:9354476-Receptors, Antigen, B-Cell,
pubmed-meshheading:9354476-Signal Transduction
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pubmed:year |
1997
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pubmed:articleTitle |
The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation.
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pubmed:affiliation |
Department of Immunology, The Tokyo Metropolitan Institute of Medical Science, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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