| pubmed-article:9354470 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9354470 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9354470 | lifeskim:mentions | umls-concept:C0024204 | lld:lifeskim |
| pubmed-article:9354470 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:9354470 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:9354470 | lifeskim:mentions | umls-concept:C0162832 | lld:lifeskim |
| pubmed-article:9354470 | lifeskim:mentions | umls-concept:C0439682 | lld:lifeskim |
| pubmed-article:9354470 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:9354470 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9354470 | pubmed:dateCreated | 1997-11-21 | lld:pubmed |
| pubmed-article:9354470 | pubmed:abstractText | For a brief period during fetal lymph node organogenesis in mice, lymph node postcapillary high endothelial venules surprisingly express the Peyer's patch addressin MAdCAM-1. This expression allows initial seeding of this incipient structure by two unusual lymphocyte populations selectively expressing the Peyer's patch homing receptor integrin alpha4beta7: CD4+CD3- oligolineage progenitors and TCR gammadelta+ T cells. We show here that CD4+CD3- cells are lineage-restricted progenitors that express surface lymphotoxin-beta (LTbeta) and the chemokine receptor BLR1 and that can become natural killer cells, dendritic antigen-presenting cells, and follicular cells of unknown outcome, but these cells do not become T or B lymphocytes. Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture. | lld:pubmed |
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| pubmed-article:9354470 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9354470 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9354470 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9354470 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9354470 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:9354470 | pubmed:author | pubmed-author:WeissmanI LIL | lld:pubmed |
| pubmed-article:9354470 | pubmed:author | pubmed-author:MebiusR ERE | lld:pubmed |
| pubmed-article:9354470 | pubmed:author | pubmed-author:RennertPP | lld:pubmed |
| pubmed-article:9354470 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9354470 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:9354470 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9354470 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9354470 | pubmed:pagination | 493-504 | lld:pubmed |
| pubmed-article:9354470 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9354470 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9354470 | pubmed:articleTitle | Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. | lld:pubmed |
| pubmed-article:9354470 | pubmed:affiliation | Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands. r.mebius.cell@med.vu.nl | lld:pubmed |
| pubmed-article:9354470 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9354470 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9354470 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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