|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1997-11-21
|
|
pubmed:abstractText |
For a brief period during fetal lymph node organogenesis in mice, lymph node postcapillary high endothelial venules surprisingly express the Peyer's patch addressin MAdCAM-1. This expression allows initial seeding of this incipient structure by two unusual lymphocyte populations selectively expressing the Peyer's patch homing receptor integrin alpha4beta7: CD4+CD3- oligolineage progenitors and TCR gammadelta+ T cells. We show here that CD4+CD3- cells are lineage-restricted progenitors that express surface lymphotoxin-beta (LTbeta) and the chemokine receptor BLR1 and that can become natural killer cells, dendritic antigen-presenting cells, and follicular cells of unknown outcome, but these cells do not become T or B lymphocytes. Since the necessity of lymphotoxin in lymphoid organ development has been shown, we propose that the novel subset of CD4+CD3-LTbeta+ fetal cells is instrumental in the development of lymphoid tissue architecture.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Blr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/LTB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ltb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Madcam1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mucoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/integrin alpha4beta7
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1074-7613
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
493-504
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9354470-Animals,
pubmed-meshheading:9354470-Animals, Newborn,
pubmed-meshheading:9354470-Antigen-Presenting Cells,
pubmed-meshheading:9354470-Antigens, CD3,
pubmed-meshheading:9354470-Antigens, CD45,
pubmed-meshheading:9354470-B-Lymphocytes,
pubmed-meshheading:9354470-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9354470-Cell Adhesion Molecules,
pubmed-meshheading:9354470-Cytotoxicity, Immunologic,
pubmed-meshheading:9354470-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:9354470-GTP-Binding Proteins,
pubmed-meshheading:9354470-Gene Expression,
pubmed-meshheading:9354470-Histocompatibility Antigens Class II,
pubmed-meshheading:9354470-Immunity, Cellular,
pubmed-meshheading:9354470-Immunoglobulins,
pubmed-meshheading:9354470-Integrins,
pubmed-meshheading:9354470-Interleukin-2,
pubmed-meshheading:9354470-Killer Cells, Natural,
pubmed-meshheading:9354470-Leukopoiesis,
pubmed-meshheading:9354470-Lymph Nodes,
pubmed-meshheading:9354470-Lymphocyte Subsets,
pubmed-meshheading:9354470-Lymphotoxin-alpha,
pubmed-meshheading:9354470-Lymphotoxin-beta,
pubmed-meshheading:9354470-Membrane Proteins,
pubmed-meshheading:9354470-Mice,
pubmed-meshheading:9354470-Mice, Inbred AKR,
pubmed-meshheading:9354470-Mice, Inbred BALB C,
pubmed-meshheading:9354470-Mice, Inbred C57BL,
pubmed-meshheading:9354470-Mucoproteins,
pubmed-meshheading:9354470-RNA, Messenger,
pubmed-meshheading:9354470-Receptors, CXCR5,
pubmed-meshheading:9354470-Receptors, Chemokine,
pubmed-meshheading:9354470-Receptors, Cytokine,
pubmed-meshheading:9354470-Spleen,
pubmed-meshheading:9354470-T-Lymphocytes
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells.
|
|
pubmed:affiliation |
Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands. r.mebius.cell@med.vu.nl
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
