| pubmed-article:9353050 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9353050 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:9353050 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9353050 | lifeskim:mentions | umls-concept:C0031272 | lld:lifeskim |
| pubmed-article:9353050 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9353050 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9353050 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:9353050 | lifeskim:mentions | umls-concept:C0040557 | lld:lifeskim |
| pubmed-article:9353050 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9353050 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9353050 | pubmed:dateCreated | 1997-11-13 | lld:pubmed |
| pubmed-article:9353050 | pubmed:abstractText | Since we previously observed a remarkable decrease in the numbers of T cells in the Peyer's patches of the small intestines in C57BL/6 mice following peroral infection with Toxoplasma gondii, we performed studies to examine the mechanism(s) whereby this decrease in numbers of the T cells occurs. We found that apoptotic cell death of CD4+ and CD8+ alphabeta T cells occurred in Peyer's patches following infection. Upregulation of Fas expression was observed in these T cells. C57BL/6-background mutant mice which lack functional Fas antigen did not develop apoptosis in their Peyer's patches following infection. Treatment of infected C57BL/6 mice with anti-gamma interferon (IFN-gamma) monoclonal antibodies prevented the upregulation of Fas on their Peyer's patch T cells and inhibited the occurrence of apoptosis of these T cells. These results indicate that IFN-gamma induces Fas-dependent apoptosis in CD4+ and CD8+ alphabeta T cells in Peyer's patches in C57BL/6 mice following peroral infection with T. gondii. | lld:pubmed |
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| pubmed-article:9353050 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9353050 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9353050 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9353050 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9353050 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9353050 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:9353050 | pubmed:author | pubmed-author:SuzukiYY | lld:pubmed |
| pubmed-article:9353050 | pubmed:author | pubmed-author:KosekJ CJC | lld:pubmed |
| pubmed-article:9353050 | pubmed:author | pubmed-author:LiesenfeldOO | lld:pubmed |
| pubmed-article:9353050 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9353050 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:9353050 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9353050 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9353050 | pubmed:pagination | 4682-9 | lld:pubmed |
| pubmed-article:9353050 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9353050 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9353050 | pubmed:articleTitle | Gamma interferon induces Fas-dependent apoptosis of Peyer's patch T cells in mice following peroral infection with Toxoplasma gondii. | lld:pubmed |
| pubmed-article:9353050 | pubmed:affiliation | Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, California 94301, USA. | lld:pubmed |
| pubmed-article:9353050 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9353050 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9353050 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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