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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1997-11-13
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pubmed:abstractText |
Since we previously observed a remarkable decrease in the numbers of T cells in the Peyer's patches of the small intestines in C57BL/6 mice following peroral infection with Toxoplasma gondii, we performed studies to examine the mechanism(s) whereby this decrease in numbers of the T cells occurs. We found that apoptotic cell death of CD4+ and CD8+ alphabeta T cells occurred in Peyer's patches following infection. Upregulation of Fas expression was observed in these T cells. C57BL/6-background mutant mice which lack functional Fas antigen did not develop apoptosis in their Peyer's patches following infection. Treatment of infected C57BL/6 mice with anti-gamma interferon (IFN-gamma) monoclonal antibodies prevented the upregulation of Fas on their Peyer's patch T cells and inhibited the occurrence of apoptosis of these T cells. These results indicate that IFN-gamma induces Fas-dependent apoptosis in CD4+ and CD8+ alphabeta T cells in Peyer's patches in C57BL/6 mice following peroral infection with T. gondii.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-1350984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-1372394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-1670604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-1710634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-2106557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-2147950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-2496163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-2960769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-3128869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-7511063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-7522637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-7530335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-7530336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-7530337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-7533498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-7533645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-7991540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-8144893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-8325338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-8419493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-8500870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-8598462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-8671678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-8758891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-8760813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9353050-8805658
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4682-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9353050-Animals,
pubmed-meshheading:9353050-Antibodies, Monoclonal,
pubmed-meshheading:9353050-Antigens, CD95,
pubmed-meshheading:9353050-Apoptosis,
pubmed-meshheading:9353050-Female,
pubmed-meshheading:9353050-Interferon-gamma,
pubmed-meshheading:9353050-Mice,
pubmed-meshheading:9353050-Mice, Inbred C57BL,
pubmed-meshheading:9353050-Peyer's Patches,
pubmed-meshheading:9353050-T-Lymphocytes,
pubmed-meshheading:9353050-Toxoplasmosis, Animal
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pubmed:year |
1997
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pubmed:articleTitle |
Gamma interferon induces Fas-dependent apoptosis of Peyer's patch T cells in mice following peroral infection with Toxoplasma gondii.
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pubmed:affiliation |
Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, California 94301, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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