| pubmed-article:9353041 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9353041 | lifeskim:mentions | umls-concept:C0079488 | lld:lifeskim |
| pubmed-article:9353041 | lifeskim:mentions | umls-concept:C0025516 | lld:lifeskim |
| pubmed-article:9353041 | lifeskim:mentions | umls-concept:C0010868 | lld:lifeskim |
| pubmed-article:9353041 | lifeskim:mentions | umls-concept:C0150543 | lld:lifeskim |
| pubmed-article:9353041 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9353041 | pubmed:dateCreated | 1997-11-13 | lld:pubmed |
| pubmed-article:9353041 | pubmed:abstractText | Treatment of the Helicobacter pylori vacuolating cytotoxin with very low concentrations of formaldehyde resulted in abrogation of toxic activity in both a HeLa cell vacuolation assay and an in vivo assay of gastric epithelial damage. Detoxification had only a minimal effect on the integrity of the oligomeric or monomeric structure. The toxoid retained the ability to bind to target cells and to induce high-titer neutralizing antibodies after immunization of rabbits. Furthermore, oral immunization of mice with the toxoid resulted in protection against infective challenge with mouse-adapted strains of H. pylori. The sensitivity of the toxin to formaldehyde treatment suggests that a few lysine residues in the protein may be essential for toxic activity and that VacA detoxified in this manner may be a potential candidate for inclusion in a vaccine against H. pylori infection and disease. | lld:pubmed |
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| pubmed-article:9353041 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9353041 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9353041 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9353041 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9353041 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:9353041 | pubmed:author | pubmed-author:MarchettiMM | lld:pubmed |
| pubmed-article:9353041 | pubmed:author | pubmed-author:MassariPP | lld:pubmed |
| pubmed-article:9353041 | pubmed:author | pubmed-author:TelfordJ LJL | lld:pubmed |
| pubmed-article:9353041 | pubmed:author | pubmed-author:GhiaraPP | lld:pubmed |
| pubmed-article:9353041 | pubmed:author | pubmed-author:RappuoliRR | lld:pubmed |
| pubmed-article:9353041 | pubmed:author | pubmed-author:NutiSS | lld:pubmed |
| pubmed-article:9353041 | pubmed:author | pubmed-author:ManettiRR | lld:pubmed |
| pubmed-article:9353041 | pubmed:author | pubmed-author:MagagnoliCC | lld:pubmed |
| pubmed-article:9353041 | pubmed:author | pubmed-author:LupettiPP | lld:pubmed |
| pubmed-article:9353041 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9353041 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:9353041 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9353041 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9353041 | pubmed:pagination | 4615-9 | lld:pubmed |
| pubmed-article:9353041 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9353041 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9353041 | pubmed:articleTitle | Detoxification of the Helicobacter pylori cytotoxin. | lld:pubmed |
| pubmed-article:9353041 | pubmed:affiliation | IRIS, Chiron-Vaccines, Siena, Italy. | lld:pubmed |
| pubmed-article:9353041 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9353041 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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