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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1997-12-10
|
| pubmed:abstractText |
The presence of pyrraline in human urine has recently been described. Using reversed-phase high-performance liquid chromatography, we measured urinary pyrraline in 45 insulin-treated diabetic patients with preserved renal function and in 30 age- and sex-matched healthy subjects. The relationship between urinary pyrraline and metabolic control parameters in the diabetic population (glycaemia, fructosamine, haemoglobin A1c, and 1-year mean haemoglobin A1c) was evaluated. The mean urinary level of pyrraline in diabetic patients with poor glycaemic control (HbA1c > 9.5%) was higher than that in healthy subjects (1.12 +/- 0.35 vs. 0.75 +/- 0.2 mumol mmol-1 creatinine, P < 0.04), whereas in patients with good to moderate glycaemic control (HbA1c < 9.5) it was slightly but not significantly higher than in healthy subjects (0.80 +/- 0.3 mumol mmol-1 creatinine vs. 0.75 +/- 0.2 mumol mmol-1 creatinine). There is a significant correlation between urinary pyrraline level and glycaemia (P < 0.008), haemoglobin A1c (P < 0.01) and 1-year mean haemoglobin A1c values (P < 0.007), but not with fructosamine. The results of the present work prove, for the first time, that glycaemic status influences circulating levels of advanced Maillard reaction products.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-formyl-5-(hydroxymethyl)pyrrole-1-...,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Fructosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Norleucine,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Urea
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0014-2972
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
767-73
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9352249-Adolescent,
pubmed-meshheading:9352249-Adult,
pubmed-meshheading:9352249-Aged,
pubmed-meshheading:9352249-Aged, 80 and over,
pubmed-meshheading:9352249-Blood Glucose,
pubmed-meshheading:9352249-Child,
pubmed-meshheading:9352249-Chromatography, High Pressure Liquid,
pubmed-meshheading:9352249-Creatinine,
pubmed-meshheading:9352249-Diabetes Mellitus, Type 1,
pubmed-meshheading:9352249-Female,
pubmed-meshheading:9352249-Fructosamine,
pubmed-meshheading:9352249-Hemoglobin A, Glycosylated,
pubmed-meshheading:9352249-Humans,
pubmed-meshheading:9352249-Maillard Reaction,
pubmed-meshheading:9352249-Male,
pubmed-meshheading:9352249-Matched-Pair Analysis,
pubmed-meshheading:9352249-Middle Aged,
pubmed-meshheading:9352249-Norleucine,
pubmed-meshheading:9352249-Pyrroles,
pubmed-meshheading:9352249-Regression Analysis,
pubmed-meshheading:9352249-Urea
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Glycaemic control and in vivo non-oxidative Maillard reaction: urinary excretion of pyrraline in diabetes patients.
|
| pubmed:affiliation |
Department of Basic Medical Sciences, Faculty of Medicine, University of Lleida, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|