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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1998-1-6
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pubmed:abstractText |
Nerve growth factor (NGF) is a neurotrophic factor that promotes the differentiation and survival of certain populations of neurons in the central and peripheral nervous systems. 7S NGF is an alpha 2 beta 2 gamma 2 complex in which the beta-NGF dimer (the active neurotrophin) is associated with two alpha-NGF and two gamma-NGF subunits, which belong to the glandular kallikrein family of serine proteinases. The gamma-NGF subunit is an active serine proteinase capable of processing the precursor form of beta-NGF, whereas alpha-NGF is an inactive serine proteinase. The structure of 7S NGF could be used as a starting point to design inhibitors that prevent NGF binding to its receptors, as a potential treatment of neurodegenerative diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1275-85
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pubmed:dateRevised |
2010-10-5
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pubmed:meshHeading |
pubmed-meshheading:9351801-Amino Acid Sequence,
pubmed-meshheading:9351801-Animals,
pubmed-meshheading:9351801-Binding Sites,
pubmed-meshheading:9351801-Crystallography, X-Ray,
pubmed-meshheading:9351801-Dimerization,
pubmed-meshheading:9351801-Enzyme Precursors,
pubmed-meshheading:9351801-Kallikreins,
pubmed-meshheading:9351801-Mice,
pubmed-meshheading:9351801-Models, Molecular,
pubmed-meshheading:9351801-Molecular Sequence Data,
pubmed-meshheading:9351801-Nerve Growth Factors,
pubmed-meshheading:9351801-Protein Binding,
pubmed-meshheading:9351801-Protein Conformation,
pubmed-meshheading:9351801-Protein Structure, Secondary,
pubmed-meshheading:9351801-Sequence Alignment,
pubmed-meshheading:9351801-Serine Endopeptidases,
pubmed-meshheading:9351801-Zinc
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pubmed:year |
1997
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pubmed:articleTitle |
Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.
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pubmed:affiliation |
Department of Crystallography, Birkbeck College, London, UK. b.bax@cryst.bbk.ac.uk
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pubmed:publicationType |
Journal Article
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