Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-12-4
pubmed:abstractText
Double-stimulation was used to demonstrate that, in a T lymphocytic cell line (CEM), phorbol myristate acetate (PMA) rapidly induced NF-kappa B through a signaling pathway which did not involve reactive oxygen species (ROS) and was different from the activation triggered by either H2O2 or tumor necrosis factor-alpha (TNF-alpha). Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/1-(5-Isoquinolinesulfonyl)-2-Methylp..., http://linkedlifedata.com/resource/pubmed/chemical/Acetylcysteine, http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species, http://linkedlifedata.com/resource/pubmed/chemical/Staurosporine, http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1071-5762
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9350434-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, pubmed-meshheading:9350434-Acetylcysteine, pubmed-meshheading:9350434-Antioxidants, pubmed-meshheading:9350434-Base Sequence, pubmed-meshheading:9350434-Binding Sites, pubmed-meshheading:9350434-Cell Line, pubmed-meshheading:9350434-Enzyme Inhibitors, pubmed-meshheading:9350434-Humans, pubmed-meshheading:9350434-Hydrogen Peroxide, pubmed-meshheading:9350434-Kinetics, pubmed-meshheading:9350434-Molecular Sequence Data, pubmed-meshheading:9350434-NF-kappa B, pubmed-meshheading:9350434-Oligodeoxyribonucleotides, pubmed-meshheading:9350434-Protein Kinase Inhibitors, pubmed-meshheading:9350434-Reactive Oxygen Species, pubmed-meshheading:9350434-Signal Transduction, pubmed-meshheading:9350434-Staurosporine, pubmed-meshheading:9350434-T-Lymphocytes, pubmed-meshheading:9350434-Tetradecanoylphorbol Acetate, pubmed-meshheading:9350434-Tumor Necrosis Factor-alpha
pubmed:year
1997
pubmed:articleTitle
Involvement of different transduction pathways in NF-kappa B activation by several inducers.
pubmed:affiliation
Laboratory of Virology, University of Liège, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't