| pubmed-article:9349869 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9349869 | lifeskim:mentions | umls-concept:C1705593 | lld:lifeskim |
| pubmed-article:9349869 | lifeskim:mentions | umls-concept:C1882780 | lld:lifeskim |
| pubmed-article:9349869 | lifeskim:mentions | umls-concept:C0282554 | lld:lifeskim |
| pubmed-article:9349869 | lifeskim:mentions | umls-concept:C1332652 | lld:lifeskim |
| pubmed-article:9349869 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9349869 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9349869 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9349869 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9349869 | pubmed:dateCreated | 1997-12-16 | lld:pubmed |
| pubmed-article:9349869 | pubmed:abstractText | Interleukin-8 possesses chemotactic-activating properties toward neutrophils, and may contribute to the pathogenesis of middle ear inflammation. GRO/CINC-1 is a rat chemokine with structural and functional homology to human interleukin-8, the induction and regulation of which in the middle ear cavity in vivo remains to be established. The production of GRO/CINC-1 in middle ear lavage and gene expression in the middle mucosa was investigated using topical inoculation with lipopolysaccharide (LPS) in the rat in vivo model. GRO/CINC-1 in middle ear lavage showed time- and dose-dependent production under LPS stimulation. The peak of the GRO/CINC-1 production was reached by 4 h after LPS 1 h exposure, whereas the level of production subsequently returned to the level without LPS stimulation at 8 h after LPS stimulation. The topical corticosteroid perfusion in the middle ear after LPS stimulation significantly reduced the production of GRO/CINC-1 in the middle ear cavity compared with that without corticosteroid. At the time of peak production, the expression of GRO/CINC-1 mRNA, evaluated using the polymerase chain reaction, was considerable in the middle ear mucosa. This investigation of the characteristics of interleukin-8-like cytokine in the middle ear cavity using a rat in vivo model has extended the functional concept of chemokines at the initial stage in otitis media. | lld:pubmed |
| pubmed-article:9349869 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9349869 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9349869 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9349869 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9349869 | pubmed:issn | 0001-6489 | lld:pubmed |
| pubmed-article:9349869 | pubmed:author | pubmed-author:HillHH | lld:pubmed |
| pubmed-article:9349869 | pubmed:author | pubmed-author:KatauraAA | lld:pubmed |
| pubmed-article:9349869 | pubmed:author | pubmed-author:YoshiokaII | lld:pubmed |
| pubmed-article:9349869 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9349869 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:9349869 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9349869 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9349869 | pubmed:pagination | 719-23 | lld:pubmed |
| pubmed-article:9349869 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9349869 | pubmed:meshHeading | pubmed-meshheading:9349869-... | lld:pubmed |
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| pubmed-article:9349869 | pubmed:meshHeading | pubmed-meshheading:9349869-... | lld:pubmed |
| pubmed-article:9349869 | pubmed:meshHeading | pubmed-meshheading:9349869-... | lld:pubmed |
| pubmed-article:9349869 | pubmed:meshHeading | pubmed-meshheading:9349869-... | lld:pubmed |
| pubmed-article:9349869 | pubmed:meshHeading | pubmed-meshheading:9349869-... | lld:pubmed |
| pubmed-article:9349869 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9349869 | pubmed:articleTitle | In vivo induction and regulation of interleukin-8-like chemokine GRO/CINC-1 in rat middle ear. | lld:pubmed |
| pubmed-article:9349869 | pubmed:affiliation | Department of Otolaryngology, Sapporo Medical University, School of Medicine, Japan. | lld:pubmed |
| pubmed-article:9349869 | pubmed:publicationType | Journal Article | lld:pubmed |
