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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-2-5
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pubmed:abstractText |
Over the past 10 years, molecular cloning has revealed the presence of 15 serotonin (5-hydroxytryptamine; 5-HT) receptor subtypes, which can be subdivided in seven subfamilies. Except for the 5-HT3 receptors, which are ligand-gated ion channels, all 5-HT receptors belong to the superfamily of G-protein-coupled receptors. The large multiplicity of 5-HT receptor subtypes has been suggested to be a direct result of the evolutionary age of the 5-HT system. Molecular information on G-protein-coupled 5-HT receptors is currently available for several mammalian species as well as for a limited number of invertebrate species (insects, molluscs). The aim of this review is to give an overview of all cloned 5-HT receptor subtypes belonging to the superfamily of G-protein-coupled receptors with specific emphasis on the pharmacological and signaling properties of the receptors upon expression in several heterologous expression systems.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/HTR1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1B,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1D,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT4,
http://linkedlifedata.com/resource/pubmed/chemical/serotonin 1E receptor,
http://linkedlifedata.com/resource/pubmed/chemical/serotonin 1F receptor,
http://linkedlifedata.com/resource/pubmed/chemical/serotonin 6 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/serotonin 7 receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
334
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-23
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9346322-Animals,
pubmed-meshheading:9346322-Aplysia,
pubmed-meshheading:9346322-Drosophila,
pubmed-meshheading:9346322-Gene Expression Regulation,
pubmed-meshheading:9346322-Humans,
pubmed-meshheading:9346322-Lymnaea,
pubmed-meshheading:9346322-Receptor, Serotonin, 5-HT1B,
pubmed-meshheading:9346322-Receptor, Serotonin, 5-HT1D,
pubmed-meshheading:9346322-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:9346322-Receptor, Serotonin, 5-HT2C,
pubmed-meshheading:9346322-Receptors, Serotonin,
pubmed-meshheading:9346322-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:9346322-Receptors, Serotonin, 5-HT4,
pubmed-meshheading:9346322-Signal Transduction,
pubmed-meshheading:9346322-Terminology as Topic
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pubmed:year |
1997
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pubmed:articleTitle |
Functional characteristics of heterologously expressed 5-HT receptors.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Research Institute Neurosciences, Vrije Universteit, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Review
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