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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1997-11-21
pubmed:abstractText
NeuroD1/beta2 is a basic helix-loop-helix (bHLH) factor expressed in the endocrine cells of the pancreas and in a subset of neurons as they undergo terminal differentiation. We now show that NeuroD1 is expressed in corticotroph cells of the pituitary gland and that it is involved in cell-specific transcription of the proopiomelanocortin (POMC) gene. It was previously shown that corticotroph-specific POMC transcription depends in part on the action of cell-restricted bHLH factors that were characterized as the CUTE (corticotroph upstream transcription element) (M. Therrien and J. Drouin, Mol. Cell. Biol. 13:2342-2353, 1993) complexes. We now demonstrate that these complexes contain NeuroD1 in association with various ubiquitous bHLH dimerization partners. The NeuroD1-containing heterodimers specifically recognize and activate transcription from the POMC promoter E box that confers transcriptional specificity. Interestingly, the NeuroD1 heterodimers activate transcription in synergy with Ptx1, a Bicoid-related homeodomain protein, which also contributes to corticotroph specificity of POMC transcription. In the adult pituitary gland, NeuroD1 transcripts are detected in POMC-expressing corticotroph cells. Taken together with the restricted pattern of Ptx1 expression, these results suggest that these two factors establish the basis of a combinatorial code for the program of corticotroph-specific gene expression.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-1317057, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-1327757, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-1358758, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-1396592, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-1505020, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-1649701, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-1704102, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-1704103, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-1846322, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-1996119, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-2046665, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-2155707, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-2156629, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-2174572, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-2200736, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-2308859, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-2440339, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-2493990, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-2503252, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-2908509, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-3123205, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-3321054, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-3431549, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-7565756, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-7708065, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-7754368, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-7774807, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-7797078, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-7830794, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-7895266, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-7909512, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-7926781, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-7961905, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8027530, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8181063, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8221886, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8269506, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8269513, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8393145, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8393146, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8455616, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8515204, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8543157, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8548800, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8581982, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8675014, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8816493, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-8858147, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-9108015, http://linkedlifedata.com/resource/pubmed/commentcorrection/9343431-9226452
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6673-82
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:9343431-Pituitary Gland, pubmed-meshheading:9343431-Cell Differentiation, pubmed-meshheading:9343431-Nerve Tissue Proteins, pubmed-meshheading:9343431-Protein Binding, pubmed-meshheading:9343431-Models, Biological, pubmed-meshheading:9343431-Tissue Distribution, pubmed-meshheading:9343431-Dimerization, pubmed-meshheading:9343431-Transcription, Genetic, pubmed-meshheading:9343431-Gene Expression Regulation, Developmental, pubmed-meshheading:9343431-DNA-Binding Proteins, pubmed-meshheading:9343431-Regulatory Sequences, Nucleic Acid, pubmed-meshheading:9343431-Transcription Factors, pubmed-meshheading:9343431-Pro-Opiomelanocortin, pubmed-meshheading:9343431-Trans-Activators, pubmed-meshheading:9343431-Homeodomain Proteins, pubmed-meshheading:9343431-Basic Helix-Loop-Helix Transcription Factors
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