Linked Life Data

9341923

Source:http://linkedlifedata.com/resource/pubmed/id/9341923

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1997-11-28
pubmed:abstractText
Enviroxime is a potent antiviral agent with broad spectrum activity in tissue culture against both rhinoviruses and enteroviruses. We have synthesized and studied a series of C2-substituted analogs in order to identify critical functionality and examine its role in antiviral activity. We have found that primary amino substitution is the most active. Ab initio calculations indicate that larger groups at C2 may provide a repulsive steric interaction at N3, and in those cases where this undesirable conformation has limited flexibility, the antiviral activity is severely reduced. Further the results show that an amino hydrogen at C2 is strongly hydrogen bonded to the N1 sulfonyl oxygen, which in the case of Enviroxime may act to enhance the activity by holding the second hydrogen in a desirable orientation for interaction at an antiviral site.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3478-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Synthesis and antiviral activity of C2 analogs of enviroxime: an exploration of the role of critical functionality.
pubmed:affiliation
Lilly Research Laboratories, Indianapolis, Indiana 46285, USA.
pubmed:publicationType
Journal Article