Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
43
pubmed:dateCreated
1997-11-28
pubmed:databankReference
pubmed:abstractText
Tec is the prototype of a recently emerging subfamily among nonreceptor type protein-tyrosine kinases and is known to become tyrosine-phosphorylated and activated by a wide range of cytokine stimulations in hematopoietic cells. Although Tec was recently shown to be involved in the cytokine-driven activation mechanism of c-fos transcription, it is yet obscure how Tec relays the signals from cell surface receptors to the nucleus. To identify signaling molecules acting downstream of Tec, we have looked for Tec-interacting proteins (TIPs) by using the yeast two-hybrid system. Here we report the identification and characterization of a novel protein, TIP3, which has been simultaneously identified by other groups as SOCS-1, JAB, or SSI-1. TIP3 carries one Src homology 2 domain with a sequence similarity to that of CIS. In 293 cells, TIP3 associates with Tec and suppresses its kinase activity. Interestingly, TIP3 can also down-regulate the activity of Jak2 but not that of Lyn. We propose that SOCS-1/JAB/SSI-1/TIP3 is a novel type of negative regulator to a subset of protein-tyrosine kinases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/JAK2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/SOCS1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling..., http://linkedlifedata.com/resource/pubmed/chemical/Tec protein-tyrosine kinase
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
272
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27178-82
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9341160-Amino Acid Sequence, pubmed-meshheading:9341160-Animals, pubmed-meshheading:9341160-B-Lymphocytes, pubmed-meshheading:9341160-Base Sequence, pubmed-meshheading:9341160-Carrier Proteins, pubmed-meshheading:9341160-Cell Line, pubmed-meshheading:9341160-Gene Library, pubmed-meshheading:9341160-Genes, fos, pubmed-meshheading:9341160-Humans, pubmed-meshheading:9341160-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:9341160-Janus Kinase 2, pubmed-meshheading:9341160-Molecular Sequence Data, pubmed-meshheading:9341160-Promoter Regions, Genetic, pubmed-meshheading:9341160-Protein-Tyrosine Kinases, pubmed-meshheading:9341160-Proto-Oncogene Proteins, pubmed-meshheading:9341160-Recombinant Proteins, pubmed-meshheading:9341160-Repressor Proteins, pubmed-meshheading:9341160-Suppressor of Cytokine Signaling Proteins, pubmed-meshheading:9341160-Transfection, pubmed-meshheading:9341160-src Homology Domains
pubmed:year
1997
pubmed:articleTitle
SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.
pubmed:affiliation
Division of Cardiology, Jichi Medical School, 3311-1 Yakushiji, Kawachi-gun, Tochigi 329-04, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't