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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
1997-10-23
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pubmed:abstractText |
Biguanides have been used in treatment of diabetes mellitus for over 30 years now. Due to frequent occurrence of lactic acidosis, particularly in patients with serious contraindications to biguanide therapy and in cases of non-compliance with dosage instructions, buformin and phenformin were taken off the market in most European countries at the end of the seventies. Metformin continued to be allowed, since the risk of lactic acidosis is 20 times less than with phenformin or buformin due to the different pharmacokinetic properties of the substance. Plenty of clinical experience has been gained with metformin, documented in a large number of reliable long-term studies.
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pubmed:language |
ger
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0723-5003
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
472-9, 505
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9340472-Biguanides,
pubmed-meshheading:9340472-Blood Glucose,
pubmed-meshheading:9340472-Diabetes Mellitus, Type 2,
pubmed-meshheading:9340472-Humans,
pubmed-meshheading:9340472-Hypoglycemic Agents,
pubmed-meshheading:9340472-Insulin Resistance,
pubmed-meshheading:9340472-Metformin
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pubmed:year |
1997
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pubmed:articleTitle |
[Value of biguanide in therapy of diabetes mellitus].
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pubmed:affiliation |
Klinik für Psychiatrie und Psychotherapie, Universität Rostock.
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pubmed:publicationType |
Journal Article,
English Abstract,
Review
|