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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-12-1
|
| pubmed:abstractText |
CdxA, a chicken homeobox-containing gene related to caudal in Drosophila, has been implicated in the regionalization of endoderm. It is reported here that, in the development of the chicken embryo, CdxA expression appears in the endoderm at day 1.5 of development as bilateral bands on either side of the splanchnopleure which later contribute to intestinal epithelium. The CdxA-expressing area extends medially and caudally as formation of the gut tube progresses. It is also shown that the rostral limit of CdxA expression demarcates the boundary between stomach and duodenum after day 3 of development. CdxA is not expressed in digestive tract appendages which open into the intestine, such as pancreas, liver and allantois. Early restriction of CdxA expression in intestinal lineage suggests that the intestinal specification involving CdxA expression commences before the gut tube is formed. The expression of CdxA in epithelial-mesenchymal tissue recombinants suggests that mesenchymal influence regulating CdxA expression plays an important role in confirming the boundary between the stomach and intestine. Chronological change in the spatial distribution of CdxA transcripts and the results of tissue recombination experiments, together with precise fate maps of early endoderm and splanchnic mesoderm, lead to a model of mechanisms by which intestinal specification is brought about.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Avian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CdxA protein, Gallus gallus,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pepsinogens,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Sucrase
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0012-1592
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
643-53
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9338600-Animals,
pubmed-meshheading:9338600-Avian Proteins,
pubmed-meshheading:9338600-Blotting, Northern,
pubmed-meshheading:9338600-Chick Embryo,
pubmed-meshheading:9338600-Chickens,
pubmed-meshheading:9338600-Cloning, Molecular,
pubmed-meshheading:9338600-Culture Techniques,
pubmed-meshheading:9338600-Endoderm,
pubmed-meshheading:9338600-Gene Expression Regulation, Developmental,
pubmed-meshheading:9338600-Genes, Homeobox,
pubmed-meshheading:9338600-Homeodomain Proteins,
pubmed-meshheading:9338600-Immunohistochemistry,
pubmed-meshheading:9338600-In Situ Hybridization,
pubmed-meshheading:9338600-Intestinal Mucosa,
pubmed-meshheading:9338600-Mesoderm,
pubmed-meshheading:9338600-Organ Specificity,
pubmed-meshheading:9338600-Pepsinogens,
pubmed-meshheading:9338600-RNA Probes,
pubmed-meshheading:9338600-Stomach, Avian,
pubmed-meshheading:9338600-Sucrase
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Early specification of intestinal epithelium in the chicken embryo: a study on the localization and regulation of CdxA expression.
|
| pubmed:affiliation |
Department of Biology, Faculty of Science, Tokyo Metropolitan University, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|