9335622

Source:http://linkedlifedata.com/resource/pubmed/id/9335622

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0026336, umls-concept:C0026882, umls-concept:C1280500, umls-concept:C1521828, umls-concept:C1882074, umls-concept:C2825492
pubmed:issue	2
pubmed:dateCreated	1997-12-8
pubmed:abstractText	Variances of evolutionary rates among lineages in some proteins are larger than those expected from simple Poisson processes. This phenomenon is called overdispersion of the molecular clock. If population size N is constant, the overdispersion is observed only in a limited range of 2N sigma under the nearly neutral mutation model, where sigma represents the standard deviation of selection coefficients of new mutants. In this paper, we investigated effects of changing population size on the evolutionary rate by computer simulations assuming the nearly neutral mutation model. The size was changed cyclically between two numbers, N1 and N2 (N1 > N2), in the simulations. The overdispersion is observed if 2N2 sigma is less than two and the state of reduced size (bottleneck state) continues for more than approximately 0.1/u generations, where u is the mutation rate. The overdispersion results mainly because the average fitnesses of only a portion of populations go down when the population size is reduced and only in these populations subsequent advantageous substitutions occur after the population size becomes large. Since the fitness reduction after the bottleneck is stochastic, acceleration of the evolutionary rate does not necessarily occur uniformly among loci. From these results, we argue that the nearly neutral mutation model is a candidate mechanism to explain the overdispersed molecular clock.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-14156929, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-14456043, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-2488476, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-2599371, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-4368400, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-4377445, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-4585855, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-5637732, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-7714912, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-7820287, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-7851772, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-7851786, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-8078402, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-8246525, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-8248159, http://linkedlifedata.com/resource/pubmed/commentcorrection/9335622-8849901
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0374636
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0016-6731
pubmed:author	pubmed-author:ArakiHH, pubmed-author:TachidaHH
pubmed:issnType	Print
pubmed:volume	147
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	907-14
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:9335622-Biological Evolution, pubmed-meshheading:9335622-Models, Genetic, pubmed-meshheading:9335622-Mutation, pubmed-meshheading:9335622-Polymorphism, Genetic
pubmed:year	1997
pubmed:articleTitle	Bottleneck effect on evolutionary rate in the nearly neutral mutation model.
pubmed:affiliation	Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't