| pubmed-article:9335332 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9335332 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:9335332 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9335332 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9335332 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9335332 | lifeskim:mentions | umls-concept:C0935992 | lld:lifeskim |
| pubmed-article:9335332 | lifeskim:mentions | umls-concept:C1148758 | lld:lifeskim |
| pubmed-article:9335332 | lifeskim:mentions | umls-concept:C1515263 | lld:lifeskim |
| pubmed-article:9335332 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:9335332 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9335332 | pubmed:dateCreated | 1997-11-3 | lld:pubmed |
| pubmed-article:9335332 | pubmed:abstractText | To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component (mTR) was deleted from the mouse germline. mTR-/- mice lacked detectable telomerase activity yet were viable for the six generations analyzed. Telomerase-deficient cells could be immortalized in culture, transformed by viral oncogenes, and generated tumors in nude mice following transformation. Telomeres were shown to shorten at a rate of 4.8+/-2.4 kb per mTR-/- generation. Cells from the fourth mTR-/- generation onward possessed chromosome ends lacking detectable telomere repeats, aneuploidy, and chromosomal abnormalities, including end-to-end fusions. These results indicate that telomerase is essential for telomere length maintenance but is not required for establishment of cell lines, oncogenic transformation, or tumor formation in mice. | lld:pubmed |
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| pubmed-article:9335332 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9335332 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9335332 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9335332 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9335332 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9335332 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9335332 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:9335332 | pubmed:author | pubmed-author:LeeH WHW | lld:pubmed |
| pubmed-article:9335332 | pubmed:author | pubmed-author:LansdorpP MPM | lld:pubmed |
| pubmed-article:9335332 | pubmed:author | pubmed-author:BlascoM AMA | lld:pubmed |
| pubmed-article:9335332 | pubmed:author | pubmed-author:GreiderC WCW | lld:pubmed |
| pubmed-article:9335332 | pubmed:author | pubmed-author:DePinhoR ARA | lld:pubmed |
| pubmed-article:9335332 | pubmed:author | pubmed-author:HandeM PMP | lld:pubmed |
| pubmed-article:9335332 | pubmed:author | pubmed-author:SamperEE | lld:pubmed |
| pubmed-article:9335332 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9335332 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:9335332 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:9335332 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9335332 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9335332 | pubmed:pagination | 25-34 | lld:pubmed |
| pubmed-article:9335332 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9335332 | pubmed:meshHeading | pubmed-meshheading:9335332-... | lld:pubmed |
| pubmed-article:9335332 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9335332 | pubmed:articleTitle | Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. | lld:pubmed |
| pubmed-article:9335332 | pubmed:affiliation | Cold Spring Harbor Laboratory, New York 11724, USA. | lld:pubmed |
| pubmed-article:9335332 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9335332 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9335332 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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