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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
21
|
| pubmed:dateCreated |
1997-12-17
|
| pubmed:databankReference | |
| pubmed:abstractText |
tailless encodes a transcription factor expressed in multiple domains in the developing embryo. Early and transient expression at the posterior pole is required to establish a domain from which the eighth abdominal segment, telson and posterior gut arise. Just a few nuclear cycles later, a brain-specific domain is initiated at the anterior; expression in this domain is maintained with complex modulations throughout embryogenesis. Expression of tailless in this domain is required to establish the most anterior region of the brain. To understand the function and regulation of these different domains of expression, we provide a detailed description of tailless expression in brain neuroblasts and show that this expression is not detectably regulated by the head gap genes buttonhead or orthodenticle, by the proneural gene lethal of scute or by tailless itself. We show that approximately 6 kb of sequenced upstream regulatory DNA can drive lacZ expression in a pattern that mimics the full tailless embryonic expression pattern. Within this sequence we identify multiple modules responsible for different aspects of the tailless pattern. In addition to identifying additional torso response elements that mediate early blastoderm polar expression, we show that the complex brain expression pattern is driven by a combination of modules; thus expression at a low level throughout the brain and at a high level in the dorsal medial portion of the brain and in the optic lobe, as well as neuroblast-specific repression are mediated by different DNA regions.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tailless protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Galactosidase,
http://linkedlifedata.com/resource/pubmed/chemical/torso protein, Drosophila
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0950-1991
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
124
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4297-308
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:9334278-Animals,
pubmed-meshheading:9334278-Blastoderm,
pubmed-meshheading:9334278-Body Patterning,
pubmed-meshheading:9334278-Brain,
pubmed-meshheading:9334278-DNA-Binding Proteins,
pubmed-meshheading:9334278-Drosophila,
pubmed-meshheading:9334278-Drosophila Proteins,
pubmed-meshheading:9334278-Embryo, Nonmammalian,
pubmed-meshheading:9334278-Female,
pubmed-meshheading:9334278-Gene Expression Regulation, Developmental,
pubmed-meshheading:9334278-Male,
pubmed-meshheading:9334278-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:9334278-Recombinant Proteins,
pubmed-meshheading:9334278-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:9334278-Repressor Proteins,
pubmed-meshheading:9334278-Sequence Analysis, DNA,
pubmed-meshheading:9334278-Transcription Factors,
pubmed-meshheading:9334278-beta-Galactosidase
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Complex regulatory region mediating tailless expression in early embryonic patterning and brain development.
|
| pubmed:affiliation |
Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA 90095-1606, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|