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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Suppl 12
|
| pubmed:dateCreated |
1997-10-21
|
| pubmed:abstractText |
This report summarizes results from a series of pilot trials using combined-modality chemoradiotherapy with paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) as a radiosensitizing agent in patients with cancers of the lung, cervix, and bladder. In a phase I study of paclitaxel/radiotherapy in patients with locally advanced non-small cell lung cancer, five paclitaxel dose levels were evaluated in conjunction with simultaneous radiation (total dose, 59.4 Gy). A minimum of five patients were treated at each dose level; paclitaxel doses ranged from 45 mg/m2 over 3 weeks (level 1) to 65 mg/m2 for 7 weeks. Of 34 enrolled patients, 25 are evaluable for toxicity and response. Side effects were generally moderate for this combined-modality therapy, although two patients at level 5 developed dose-limiting toxicities (grade 4 esophagitis and grade 3 pneumonitis). Among 25 evaluable patients, complete and partial response rates were 4% (one patient) and 64% (16 patients), respectively; eight patients had a minor response. Median survival was 6 months (range, 1 to 20 months). Therapy was well tolerated, suggesting that the combined modalities offer a practical, effective therapy for patients with non-small cell disease. A paclitaxel dose of 55 mg/m2 is recommended for further study of combined-modality chemoradiotherapy in this clinical setting. In another trial, 33 women with inoperable, locally advanced cervical cancer received carboplatin 50 mg/m2 via intravenous infusion simultaneously with external-beam radiation therapy and vaginal brachytherapy, to define the regimen's toxicity and safety. Among the 33 women, 78% achieved a complete response to therapy. The investigators next conducted a trial of paclitaxel 50 mg/m2 given weekly over 3 hours with the previous carboplatin/radiotherapy regimen in four women and documented two partial responses, one near-complete response, and one minor response, with moderate, manageable toxicity. In a final case report on a patient with recurrent bladder cancer, simultaneous radiotherapy and weekly paclitaxel 50 mg/m2 intravenously over 3 hours yielded a partial remission, prompting the investigators to plan a phase I study to confirm the regimen's efficacy and safety. Additional planned studies include a phase I trial of simultaneous chemoradiotherapy in patients with cancer of the head and neck.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0093-7754
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S12-101-S12-105
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9331131-Adult,
pubmed-meshheading:9331131-Aged,
pubmed-meshheading:9331131-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:9331131-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9331131-Carboplatin,
pubmed-meshheading:9331131-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:9331131-Clinical Trials as Topic,
pubmed-meshheading:9331131-Combined Modality Therapy,
pubmed-meshheading:9331131-Female,
pubmed-meshheading:9331131-Humans,
pubmed-meshheading:9331131-Lung Neoplasms,
pubmed-meshheading:9331131-Male,
pubmed-meshheading:9331131-Middle Aged,
pubmed-meshheading:9331131-Paclitaxel,
pubmed-meshheading:9331131-Radiation-Sensitizing Agents,
pubmed-meshheading:9331131-Survival Analysis,
pubmed-meshheading:9331131-Urinary Bladder Neoplasms,
pubmed-meshheading:9331131-Uterine Cervical Neoplasms
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Simultaneous paclitaxel and radiotherapy: initial clinical experience in lung cancer and other malignancies.
|
| pubmed:affiliation |
Department of Radiation Medicine, Städtische Kliniken Offenbach, Germany.
|
| pubmed:publicationType |
Journal Article,
Review,
Case Reports
|