Linked Life Data

9329076

Source:http://linkedlifedata.com/resource/pubmed/id/9329076

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-2-6
pubmed:abstractText
The beta-2 selective adrenergic agonist clenbuterol produces discriminative stimulus effects in rats. Administration of beta adrenergic agonists that do not cross the blood-brain barrier well following peripheral administration either failed to substitute for clenbuterol or resulted in chance levels of drug-appropriate responding; this suggested central mediation of the effects of clenbuterol. This interpretation was supported by the finding that the centrally acting beta adrenergic antagonist propranolol antagonized the discriminative stimulus effects of clenbuterol more potently than did CGP-12177, a hydrophilic beta adrenergic antagonist that has been shown to have very limited central activity. Antagonism experiments using subtype-selective antagonists showed that the beta-2 selective antagonist ICI 118,551 more potently antagonized the discriminative effects of the training dose of clenbuterol than did the beta-1 selective antagonist betaxolol. The present results indicate that the discriminative stimulus effects of clenbuterol provide an in vivo index of activation of central beta-2 adrenergic receptors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
813-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:9329076-Adrenergic beta-1 Receptor Agonists, pubmed-meshheading:9329076-Adrenergic beta-1 Receptor Antagonists, pubmed-meshheading:9329076-Adrenergic beta-2 Receptor Agonists, pubmed-meshheading:9329076-Adrenergic beta-2 Receptor Antagonists, pubmed-meshheading:9329076-Adrenergic beta-Agonists, pubmed-meshheading:9329076-Adrenergic beta-Antagonists, pubmed-meshheading:9329076-Animals, pubmed-meshheading:9329076-Chemistry, Physical, pubmed-meshheading:9329076-Cholinergic Antagonists, pubmed-meshheading:9329076-Clenbuterol, pubmed-meshheading:9329076-Discrimination (Psychology), pubmed-meshheading:9329076-Male, pubmed-meshheading:9329076-Physicochemical Phenomena, pubmed-meshheading:9329076-Rats, pubmed-meshheading:9329076-Rats, Sprague-Dawley, pubmed-meshheading:9329076-Receptors, Adrenergic, beta-2
pubmed:year
1997
pubmed:articleTitle
Pharmacological characterization of the discriminative stimulus effects of clenbuterol in rats.
pubmed:affiliation
Department of Pharmacology, Louisiana State University School of Medicine, Shreveport 71130, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.