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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1980-3-17
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pubmed:abstractText |
We have isolated clones of alloreactive T cells by soft agar cloning of primed responder cells contained in serially restimulated, mixed lymphocyte cultures. These clones recognize unique mixed lymphocyte reaction (MLR) stimulating determinants present on (C57B/6 X A/J)F1 (B6A) spleen cells. By assaying the reactivity patterns of these clones on a panel of stimulator cells, we have identified at least three separate "specificities" of alloreactive T cell clones. Several clones exhibiting one of these three reactivity patterns have been isolated on many occasions from different experiments. Using such clones of alloreactive T cells, we have identified and are attempting to define crossreactive MLR stimulating determinants exhibited by a panel of stimulator cells. Recognition by certain clones of a shared MLR determinant(s) on B6A and DBA/2 and of the lack of this determinant(s) on B6 stimulator cells questions current concepts concerning the nature of MLR stimulating determinants and T cell recognition of alloantigens.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5863-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:93286-Animals,
pubmed-meshheading:93286-Clone Cells,
pubmed-meshheading:93286-Cross Reactions,
pubmed-meshheading:93286-Epitopes,
pubmed-meshheading:93286-H-2 Antigens,
pubmed-meshheading:93286-Immunologic Techniques,
pubmed-meshheading:93286-Isoantigens,
pubmed-meshheading:93286-Lymphocyte Activation,
pubmed-meshheading:93286-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:93286-Male,
pubmed-meshheading:93286-Mice,
pubmed-meshheading:93286-Mice, Inbred Strains,
pubmed-meshheading:93286-T-Lymphocytes
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pubmed:year |
1979
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pubmed:articleTitle |
Crossreactive mixed lymphocyte reaction determinants recognized by cloned alloreactive T cells.
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pubmed:publicationType |
Journal Article
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