| pubmed-article:9328113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9328113 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9328113 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:9328113 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9328113 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9328113 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9328113 | lifeskim:mentions | umls-concept:C0334094 | lld:lifeskim |
| pubmed-article:9328113 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:9328113 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9328113 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9328113 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9328113 | pubmed:dateCreated | 1997-10-23 | lld:pubmed |
| pubmed-article:9328113 | pubmed:abstractText | To investigate whether defective costimulatory signals could be involved in the loss of T lymphocyte functions during HIV-1 infection, we tested the effect of CD28 costimulation on both T cell receptor/CD3 and HIV-1 antigen-induced proliferative responses. Although CD3-mediated responses significantly decreased with more advanced stages of HIV-1 infection, the ability of potentiating the responses through CD28 costimulation was maintained at all stages and did not differ from that of HIV-1- subjects. When CD28 costimulation was studied in lymphocyte cultures stimulated with HIV-1 gp160 or p24, potentiation was seen only when a significant response was present without additional CD28 triggering, namely in subjects receiving active immunization with recombinant gp160. These results confirm the integrity of the CD28 pathway of costimulation during HIV-1 infection, and suggest that lymphocytes responding to soluble HIV-1 antigen are not deleted in HIV-1-infected patients, but do not receive significant priming during the natural course of the infection. | lld:pubmed |
| pubmed-article:9328113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9328113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9328113 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9328113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9328113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9328113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9328113 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9328113 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:9328113 | pubmed:author | pubmed-author:AiutiFF | lld:pubmed |
| pubmed-article:9328113 | pubmed:author | pubmed-author:RossiLL | lld:pubmed |
| pubmed-article:9328113 | pubmed:author | pubmed-author:CassoneAA | lld:pubmed |
| pubmed-article:9328113 | pubmed:author | pubmed-author:PaganelliRR | lld:pubmed |
| pubmed-article:9328113 | pubmed:author | pubmed-author:CarlesimoMM | lld:pubmed |
| pubmed-article:9328113 | pubmed:author | pubmed-author:BernardiM LML | lld:pubmed |
| pubmed-article:9328113 | pubmed:author | pubmed-author:PontesilliOO | lld:pubmed |
| pubmed-article:9328113 | pubmed:author | pubmed-author:VaraniA RAR | lld:pubmed |
| pubmed-article:9328113 | pubmed:author | pubmed-author:GuerraE CEC | lld:pubmed |
| pubmed-article:9328113 | pubmed:author | pubmed-author:MazzoneA MAM | lld:pubmed |
| pubmed-article:9328113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9328113 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:9328113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9328113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9328113 | pubmed:pagination | 406-11 | lld:pubmed |
| pubmed-article:9328113 | pubmed:dateRevised | 2008-11-20 | lld:pubmed |
| pubmed-article:9328113 | pubmed:meshHeading | pubmed-meshheading:9328113-... | lld:pubmed |
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| pubmed-article:9328113 | pubmed:meshHeading | pubmed-meshheading:9328113-... | lld:pubmed |
| pubmed-article:9328113 | pubmed:meshHeading | pubmed-meshheading:9328113-... | lld:pubmed |
| pubmed-article:9328113 | pubmed:meshHeading | pubmed-meshheading:9328113-... | lld:pubmed |
| pubmed-article:9328113 | pubmed:meshHeading | pubmed-meshheading:9328113-... | lld:pubmed |
| pubmed-article:9328113 | pubmed:meshHeading | pubmed-meshheading:9328113-... | lld:pubmed |
| pubmed-article:9328113 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9328113 | pubmed:articleTitle | CD28 costimulation and T lymphocyte proliferative responses in HIV-1 infection. | lld:pubmed |
| pubmed-article:9328113 | pubmed:affiliation | Department of Clinical Medicine, University of Rome La Sapienza, Italy. | lld:pubmed |
| pubmed-article:9328113 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9328113 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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