pubmed-article:9326659 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9326659 | lifeskim:mentions | umls-concept:C0004422 | lld:lifeskim |
pubmed-article:9326659 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
pubmed-article:9326659 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
pubmed-article:9326659 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
pubmed-article:9326659 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
pubmed-article:9326659 | pubmed:issue | 21 | lld:pubmed |
pubmed-article:9326659 | pubmed:dateCreated | 1997-11-24 | lld:pubmed |
pubmed-article:9326659 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9326659 | pubmed:abstractText | Genetic studies in chickens and receptor interference experiments have indicated that avian leukosis virus (ALV)-E may utilize a cellular receptor related to the receptor for ALV-B and ALV-D. Recently, we cloned CAR1, a tumor necrosis factor receptor (TNFR)-related protein, that serves as a cellular receptor for ALV-B and ALV-D. To determine whether the cellular receptor for ALV-E is a CAR1-like protein, a cDNA library was made from turkey embryo fibroblasts (TEFs), which are susceptible to ALV-E infection, but not to infection by ALV-B and ALV-D. The cDNA library was screened with a radioactively labeled CAR1 cDNA probe, and clones that hybridized with the probe were isolated. A 2.3-kb cDNA clone was identified that conferred susceptibility to ALV-E infection, but not to ALV-B infection, when expressed in transfected human 293 cells. The functional cDNA clone is predicted to encode a 368 amino acid protein with significant amino acid similarity to CAR1. Like CAR1, the TEF protein is predicted to have two extracellular TNFR-like cysteine-rich domains and a putative death domain similar to those of TNFR I and Fas. Flow cytometric analysis and immunoprecipitation experiments demonstrated specific binding between the TEF CAR1-related protein and an immunoadhesin composed of the surface (SU) envelope protein of subgroup E (RAV-0) virus fused to the constant region of a rabbit immunoglobulin. These two activities of the TEF CAR1-related protein, specific binding to ALV-E SU and permitting entry only of ALV-E, have unambiguously identified this protein as a cellular receptor specific for subgroup E ALV. | lld:pubmed |
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pubmed-article:9326659 | pubmed:language | eng | lld:pubmed |
pubmed-article:9326659 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9326659 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:9326659 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9326659 | pubmed:month | Oct | lld:pubmed |
pubmed-article:9326659 | pubmed:issn | 0027-8424 | lld:pubmed |
pubmed-article:9326659 | pubmed:author | pubmed-author:YoungJ AJA | lld:pubmed |
pubmed-article:9326659 | pubmed:author | pubmed-author:NaughtonJJ | lld:pubmed |
pubmed-article:9326659 | pubmed:author | pubmed-author:BrojatschJJ | lld:pubmed |
pubmed-article:9326659 | pubmed:author | pubmed-author:RollsM MMM | lld:pubmed |
pubmed-article:9326659 | pubmed:author | pubmed-author:AdkinsH BHB | lld:pubmed |
pubmed-article:9326659 | pubmed:author | pubmed-author:PesolaJ MJM | lld:pubmed |
pubmed-article:9326659 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9326659 | pubmed:day | 14 | lld:pubmed |
pubmed-article:9326659 | pubmed:volume | 94 | lld:pubmed |
pubmed-article:9326659 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9326659 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9326659 | pubmed:pagination | 11617-22 | lld:pubmed |
pubmed-article:9326659 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:9326659 | pubmed:year | 1997 | lld:pubmed |
pubmed-article:9326659 | pubmed:articleTitle | Identification of a cellular receptor for subgroup E avian leukosis virus. | lld:pubmed |
pubmed-article:9326659 | pubmed:affiliation | Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. | lld:pubmed |
pubmed-article:9326659 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9326659 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:9326659 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:664712 | entrezgene:pubmed | pubmed-article:9326659 | lld:entrezgene |
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