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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-11-6
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pubmed:abstractText |
Expression of certain mammalian protein kinase C (PKC) isoforms inhibits the proliferation of Schizosaccharomyces pombe (Goode et al., Mol. Biol. Cell 5 (1994) 907-920). We have taken advantage of this fact to determine the in vivo isoform preference of a number of PKC inhibitors, using a microtitre plate assay which allows rapid screening. This in vivo model has revealed previously unreported preferences; calphostin C is a more efficient inhibitor of the novel PKCS than chelerythrine chloride whereas the efficiencies are reversed for inhibition of the classical PKCgamma. We have also shown that the anti-leukaemic agent bryostatin 1 inhibits or activates in vivo in an isoform-specific manner.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetophenones,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Benzophenanthridines,
http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Bryostatins,
http://linkedlifedata.com/resource/pubmed/chemical/Carbazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Go 6976,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lactones,
http://linkedlifedata.com/resource/pubmed/chemical/Macrolides,
http://linkedlifedata.com/resource/pubmed/chemical/Maleimides,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Phenanthridines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-delta,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/bisindolylmaleimide,
http://linkedlifedata.com/resource/pubmed/chemical/bryostatin 1,
http://linkedlifedata.com/resource/pubmed/chemical/calphostin C,
http://linkedlifedata.com/resource/pubmed/chemical/chelerythrine,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C gamma,
http://linkedlifedata.com/resource/pubmed/chemical/rottlerin
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
415
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9326378-Acetophenones,
pubmed-meshheading:9326378-Alkaloids,
pubmed-meshheading:9326378-Benzophenanthridines,
pubmed-meshheading:9326378-Benzopyrans,
pubmed-meshheading:9326378-Bryostatins,
pubmed-meshheading:9326378-Carbazoles,
pubmed-meshheading:9326378-Enzyme Activation,
pubmed-meshheading:9326378-Enzyme Inhibitors,
pubmed-meshheading:9326378-Indoles,
pubmed-meshheading:9326378-Isoenzymes,
pubmed-meshheading:9326378-Lactones,
pubmed-meshheading:9326378-Macrolides,
pubmed-meshheading:9326378-Maleimides,
pubmed-meshheading:9326378-Naphthalenes,
pubmed-meshheading:9326378-Phenanthridines,
pubmed-meshheading:9326378-Protein Kinase C,
pubmed-meshheading:9326378-Protein Kinase C-delta,
pubmed-meshheading:9326378-Recombinant Proteins,
pubmed-meshheading:9326378-Schizosaccharomyces,
pubmed-meshheading:9326378-Sphingosine,
pubmed-meshheading:9326378-Tetradecanoylphorbol Acetate,
pubmed-meshheading:9326378-Transformation, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
Isoform specificity of activators and inhibitors of protein kinase C gamma and delta.
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pubmed:affiliation |
Biochemistry Department, Oxford University, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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