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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0018894,
umls-concept:C0021745,
umls-concept:C0026809,
umls-concept:C0026913,
umls-concept:C0079189,
umls-concept:C0185117,
umls-concept:C0205216,
umls-concept:C0205263,
umls-concept:C0231204,
umls-concept:C0332307,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1997-11-6
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pubmed:abstractText |
Mycobacterium avium is an intracellular microorganism that infects and multiplies within macrophages. Cell-mediated immunity plays an important role in host defense. Two cytokines, interleukin 12 (IL-12) and interferon-gamma-inducing factor (IGIF), produced mainly by macrophages, are critical for the development of type 1 helper T (Th1) cell/interferon-gamma (IFN-gamma) responses and cell-mediated immunity. In this report, by using a mouse model of disseminated M. avium infection, we demonstrate that genetically susceptible BALB/c mice show decreased expression of IL-12 and IGIF in association with a diminished IFN-gamma/Th1 response. Conversely, resistant DBA/2 mice exhibited increased expression of IL-12, IGIF, and IFN-gamma. In both strains of infected mice, the level of IL-4/Th2 response was similar. These results suggest that decreased expression of IL-12 and IGIF leads to a diminished Th1 response without reciprocal enhanced Th2 responses in susceptible mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0090-1229
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9325078-Animals,
pubmed-meshheading:9325078-Base Sequence,
pubmed-meshheading:9325078-Cytokines,
pubmed-meshheading:9325078-DNA Primers,
pubmed-meshheading:9325078-Female,
pubmed-meshheading:9325078-Gene Expression,
pubmed-meshheading:9325078-Immunity, Cellular,
pubmed-meshheading:9325078-Interferon Inducers,
pubmed-meshheading:9325078-Interferon-gamma,
pubmed-meshheading:9325078-Interleukin-12,
pubmed-meshheading:9325078-Interleukin-18,
pubmed-meshheading:9325078-Mice,
pubmed-meshheading:9325078-Mice, Inbred BALB C,
pubmed-meshheading:9325078-Mice, Inbred DBA,
pubmed-meshheading:9325078-Mycobacterium avium,
pubmed-meshheading:9325078-Polymerase Chain Reaction,
pubmed-meshheading:9325078-RNA, Messenger,
pubmed-meshheading:9325078-Th1 Cells,
pubmed-meshheading:9325078-Tuberculosis
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pubmed:year |
1997
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pubmed:articleTitle |
Decreased expression of cytokines that induce type 1 helper T cell/interferon-gamma responses in genetically susceptible mice infected with Mycobacterium avium.
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pubmed:affiliation |
Department of Host Defenses, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan. kaz-koba@sa2.so-net.or.jp
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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