Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
13
|
pubmed:dateCreated |
1997-10-24
|
pubmed:abstractText |
The effect of immunoneutralization of beta-endorphin on the suckling-induced prolactin increase and on the activity of the tuberoinfundibular dopaminergic (TIDA) neurons was determined in lactating female rats between days 8 - 12 post-partum. Two antisera were used in the immunoneutralization studies. Both were specific for beta-endorphin, exhibiting little cross reactivity with met- or leu-enkephalin or dynorphin. Antisera to beta-endorphin completely abolished the suckling-induced prolactin increase indicating that this endogenous opioid peptide is involved in this response. Suckling significantly inhibited DOPA accumulation in the median eminence and antiserum to beta-endorphin did not prevent this inhibition. Additionally, 5-endorphin antiserum significantly reduced TIDA neural activity even in pup-deprived dams. These results indicate that beta-endorphin is involved in the prolactin secretory response to suckling but that inhibition of TIDA neuronal activity is not its mechanism of action. Other possible mechanisms are discussed.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0024-3205
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
61
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1301-11
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:9324072-Animals,
pubmed-meshheading:9324072-Antibody Specificity,
pubmed-meshheading:9324072-Arcuate Nucleus,
pubmed-meshheading:9324072-Dihydroxyphenylalanine,
pubmed-meshheading:9324072-Dopamine,
pubmed-meshheading:9324072-Female,
pubmed-meshheading:9324072-Immune Sera,
pubmed-meshheading:9324072-Lactation,
pubmed-meshheading:9324072-Male,
pubmed-meshheading:9324072-Median Eminence,
pubmed-meshheading:9324072-Prolactin,
pubmed-meshheading:9324072-Rats,
pubmed-meshheading:9324072-Rats, Sprague-Dawley,
pubmed-meshheading:9324072-Tuber Cinereum,
pubmed-meshheading:9324072-beta-Endorphin
|
pubmed:year |
1997
|
pubmed:articleTitle |
Immunoneutralization of beta-endorphin blocks prolactin release during suckling without affecting tuberoinfundibular dopaminergic neural activity.
|
pubmed:affiliation |
Department of Zoology, Center for Neuroscience, Miami University, Oxford, OH 45056, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|