Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1997-10-23
|
| pubmed:abstractText |
An insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene has been identified that determines most of the plasma ACE activity genetically. Association of the D allele with insulin sensitivity and of the D/D genotype with coronary heart disease (CHD) has been reported in various ethnic populations. To study the role of this genetic polymorphism in patients with hypertension, non-insulin-dependent diabetes mellitus (NIDDM), and NIDDM with CHD in a Taiwanese population, we used a polymerase chain reaction (PCR)-based genotyping technique with an insertion-specific primer for confirmation of the I allele. One hundred ninety-seven unrelated normal controls, 67 subjects with hypertension, 107 subjects with NIDDM, and 70 subjects with NIDDM and CHD were recruited for this study; all were Han Chinese. Subjects without a history of diabetes were studied by a standard 75-g oral glucose tolerance test. Hypertension was diagnosed according to the Fifth Joint National Committee criteria, and CHD was confirmed by a history of acute myocardial infarction and coronary angiographic intervention. The frequency of the I allele of the ACE gene in the normal population was 64.2%, which was higher than reported in white populations. The prevalence of the I allele of the ACE gene was not significantly increased in subjects with hypertension (73.1%), NIDDM (62.1%), and NIDDM with CHD (65%) compared with healthy controls. The I allele of the ACE gene did not correlate with demographic and metabolic variables. I/D polymorphism of the ACE gene is not a marker for hypertension, NIDDM, or CHD in this Taiwanese population.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0026-0495
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1211-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9322809-Age of Onset,
pubmed-meshheading:9322809-Alleles,
pubmed-meshheading:9322809-Analysis of Variance,
pubmed-meshheading:9322809-Coronary Disease,
pubmed-meshheading:9322809-DNA,
pubmed-meshheading:9322809-DNA Primers,
pubmed-meshheading:9322809-DNA Transposable Elements,
pubmed-meshheading:9322809-Diabetes Mellitus, Type 2,
pubmed-meshheading:9322809-Diabetic Angiopathies,
pubmed-meshheading:9322809-Ethnic Groups,
pubmed-meshheading:9322809-Female,
pubmed-meshheading:9322809-Humans,
pubmed-meshheading:9322809-Hypertension,
pubmed-meshheading:9322809-Male,
pubmed-meshheading:9322809-Middle Aged,
pubmed-meshheading:9322809-Peptidyl-Dipeptidase A,
pubmed-meshheading:9322809-Polymerase Chain Reaction,
pubmed-meshheading:9322809-Polymorphism, Genetic,
pubmed-meshheading:9322809-Reference Values,
pubmed-meshheading:9322809-Sequence Deletion,
pubmed-meshheading:9322809-Taiwan
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients with hypertension, non-insulin-dependent diabetes mellitus, and coronary heart disease in Taiwan.
|
| pubmed:affiliation |
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|