| pubmed-article:9321831 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9321831 | lifeskim:mentions | umls-concept:C0079281 | lld:lifeskim |
| pubmed-article:9321831 | lifeskim:mentions | umls-concept:C0026820 | lld:lifeskim |
| pubmed-article:9321831 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:9321831 | lifeskim:mentions | umls-concept:C0011570 | lld:lifeskim |
| pubmed-article:9321831 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:9321831 | pubmed:issue | 3 Pt 2 | lld:pubmed |
| pubmed-article:9321831 | pubmed:dateCreated | 1997-10-23 | lld:pubmed |
| pubmed-article:9321831 | pubmed:abstractText | Lipopolysaccharide (LPS) induces cardiac depression by activating nitric oxide pathways to increase guanosine 3',5'-cyclic monophosphate (cGMP), a second messenger of nitric oxide. Endothelin-1 (ET-1) may interact with nitric oxide pathways. We hypothesized that ET-1 modulates LPS-induced contractile depression in cardiac myocytes. Adult rabbit cardiac myocytes exposed to LPS (10 ng/ml) developed decreased cell shortening after 6 h, with an increase in cardiac cGMP levels [606 +/- 36 (SE) fmol/mg protein] compared with control myocytes (360 +/- 26 fmol/mg protein, P < 0.05). LPS effects were completely blocked by coincubation with the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (1 mM). Coincubation with ET-1 (10 nM) attenuated the contractile depression and increase in cGMP with LPS (482 +/- 28 fmol/mg protein, P < 0.05 vs. LPS alone). ET-1 alone did not alter cGMP levels (350 +/- 30 fmol/mg protein). ET-1 effects on contractile function were blocked by BQ-123 (10 microM), a selective ET-1 type A receptor antagonist. We conclude that ET-1 ameliorates LPS-induced contractile depression in cardiac myocytes by attenuating LPS effects on nitric oxide-cGMP pathways. | lld:pubmed |
| pubmed-article:9321831 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9321831 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321831 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9321831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9321831 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9321831 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9321831 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9321831 | pubmed:author | pubmed-author:YasudaSS | lld:pubmed |
| pubmed-article:9321831 | pubmed:author | pubmed-author:LeeW KWK | lld:pubmed |
| pubmed-article:9321831 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9321831 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9321831 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9321831 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9321831 | pubmed:pagination | H1403-7 | lld:pubmed |
| pubmed-article:9321831 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:meshHeading | pubmed-meshheading:9321831-... | lld:pubmed |
| pubmed-article:9321831 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9321831 | pubmed:articleTitle | Endothelin-1 ameliorates contractile depression by lipopolysaccharide in cardiac myocytes. | lld:pubmed |
| pubmed-article:9321831 | pubmed:affiliation | Department of Medicine, Veterans Affairs San Diego Healthcare System, California, USA. | lld:pubmed |
| pubmed-article:9321831 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9321831 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9321831 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9321831 | lld:pubmed |
