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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0017262,
umls-concept:C0185117,
umls-concept:C0205147,
umls-concept:C0205314,
umls-concept:C0475264,
umls-concept:C0600261,
umls-concept:C0679622,
umls-concept:C0936012,
umls-concept:C1171362,
umls-concept:C1332071,
umls-concept:C1421535,
umls-concept:C1421536,
umls-concept:C1515670,
umls-concept:C1519595,
umls-concept:C2700283,
umls-concept:C2911684
|
| pubmed:issue |
10
|
| pubmed:dateCreated |
1997-11-18
|
| pubmed:databankReference | |
| pubmed:abstractText |
The X inactivation center candidate region (Xic/XIC in mouse and human) is poorly characterized for the presence of transcription units. Only two conserved genes have been isolated to date, Xist/XIST and Cdx4/CDX4. The other known gene lying within this region, Tsx, has been identified so far only in rodents by analyzing the complete genomic sequence of a 94-kb region distal to Xist. Here, we report the characterization of an additional gene lying within this 94-kb sequenced region. Brx, for Brain X-linked gene, is a rare transcript preferentially expressed in the brain. It is normally X-inactivated in the mouse. Localisation of BRX, its human homolog has shown the gene to be located within the orthologous but inverted human CDX4-XIST segment. These results suggest that the gene order of the region encompassing the Cdx4-Xist interval in the mouse is similar in human. Comparison of the Xist-Brx and Brx-Cdx4 regions in mouse and human indicates that these intervals are three times longer in human than in mouse. BRX is a new potential candidate for one of the X-linked mental retardation syndromes mapped within the pericentromeric region of the human X Chromosome (Chr).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0938-8990
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
760-6
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9321471-Amino Acid Sequence,
pubmed-meshheading:9321471-Animals,
pubmed-meshheading:9321471-Base Sequence,
pubmed-meshheading:9321471-Brain Chemistry,
pubmed-meshheading:9321471-Chromosome Mapping,
pubmed-meshheading:9321471-Chromosomes, Artificial, Yeast,
pubmed-meshheading:9321471-Conserved Sequence,
pubmed-meshheading:9321471-DNA,
pubmed-meshheading:9321471-DNA, Complementary,
pubmed-meshheading:9321471-Gene Expression,
pubmed-meshheading:9321471-Genetic Linkage,
pubmed-meshheading:9321471-Humans,
pubmed-meshheading:9321471-Mice,
pubmed-meshheading:9321471-Molecular Sequence Data,
pubmed-meshheading:9321471-Polymerase Chain Reaction,
pubmed-meshheading:9321471-RNA,
pubmed-meshheading:9321471-Sequence Alignment,
pubmed-meshheading:9321471-Sequence Analysis, DNA,
pubmed-meshheading:9321471-X Chromosome
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region.
|
| pubmed:affiliation |
CNRS UA 1968, Génétique Moléculaire Murine, Institut Pasteur, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|