pubmed-article:9315667 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C1413159 | lld:lifeskim |
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pubmed-article:9315667 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C1418295 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C1854359 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C1422480 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C0083956 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C2346501 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:9315667 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:9315667 | pubmed:issue | 10 | lld:pubmed |
pubmed-article:9315667 | pubmed:dateCreated | 1997-10-23 | lld:pubmed |
pubmed-article:9315667 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9315667 | pubmed:abstractText | Polycomb (Pc) is involved in the stable and heritable repression of homeotic gene activity during Drosophila development. Here, we report the identification of a novel human Pc homolog, hPc2. This gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. To study the functions of the novel human Pc homolog, we generated a mutant protein, delta hPc2, which lacks an evolutionarily conserved C-terminal domain. This C-terminal domain is important for hPc2 function, since the delta hPc2 mutant protein which lacks the C-terminal domain is unable to repress gene activity. Expression of the delta hPc2 protein, but not of the wild-type hPc2 protein, results in cellular transformation of mammalian cell lines as judged by phenotypic changes, altered marker gene expression, and anchorage-independent growth. Specifically in delta hPc2-transformed cells, the expression of the c-myc proto-oncogene is strongly enhanced and serum deprivation results in apoptosis. In contrast, overexpression of the wild-type hPc2 protein results in decreased c-myc expression. Our data suggest that hPc2 is a repressor of proto-oncogene activity and that interference with hPc2 function can lead to derepression of proto-oncogene transcription and subsequently to cellular transformation. | lld:pubmed |
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pubmed-article:9315667 | pubmed:language | eng | lld:pubmed |
pubmed-article:9315667 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9315667 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:9315667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9315667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9315667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9315667 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9315667 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9315667 | pubmed:month | Oct | lld:pubmed |
pubmed-article:9315667 | pubmed:issn | 0270-7306 | lld:pubmed |
pubmed-article:9315667 | pubmed:author | pubmed-author:van DrielRR | lld:pubmed |
pubmed-article:9315667 | pubmed:author | pubmed-author:OlsonD JDJ | lld:pubmed |
pubmed-article:9315667 | pubmed:author | pubmed-author:OtteA PAP | lld:pubmed |
pubmed-article:9315667 | pubmed:author | pubmed-author:LambrechtsCC | lld:pubmed |
pubmed-article:9315667 | pubmed:author | pubmed-author:van der... | lld:pubmed |
pubmed-article:9315667 | pubmed:author | pubmed-author:HamerK MKM | lld:pubmed |
pubmed-article:9315667 | pubmed:author | pubmed-author:GunsterM JMJ | lld:pubmed |
pubmed-article:9315667 | pubmed:author | pubmed-author:SatijnD PDP | lld:pubmed |
pubmed-article:9315667 | pubmed:author | pubmed-author:MasselinkHH | lld:pubmed |
pubmed-article:9315667 | pubmed:author | pubmed-author:SewaltR GRG | lld:pubmed |
pubmed-article:9315667 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9315667 | pubmed:volume | 17 | lld:pubmed |
pubmed-article:9315667 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9315667 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9315667 | pubmed:pagination | 6076-86 | lld:pubmed |
pubmed-article:9315667 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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