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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0020964,
umls-concept:C0027651,
umls-concept:C0035668,
umls-concept:C0085136,
umls-concept:C0205263,
umls-concept:C0262950,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C1947910,
umls-concept:C2752151,
umls-concept:C2828366
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pubmed:issue |
7
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pubmed:dateCreated |
1997-11-13
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pubmed:abstractText |
Recent studies have shown that the brain is not a barrier to successful active immunotherapy that uses gene-modified autologous tumor cell vaccines. In this study, we compared the efficacy of two types of vaccines for the treatment of tumors within the central nervous system (CNS): dendritic cell (DC)-based vaccines pulsed with either tumor extract or tumor RNA, and cytokine gene-modified tumor vaccines. Using the B16/F10 murine melanoma (B16) as a model for CNS tumor, we show that vaccination with bone marrow-generated DCs, pulsed with either B16 cell extract or B16 total RNA, can induce specific cytotoxic T lymphocytes against B16 tumor cells. Both types of DC vaccines were able to protect animals from tumors located in the CNS. DC-based vaccines also led to prolonged survival in mice with tumors placed before the initiation of vaccine therapy. The DC-based vaccines were at least as effective, if not more so, as vaccines containing B16 tumor cells in which the granulocytic macrophage colony-stimulating factor gene had been modified. These data support the use of DC-based vaccines for the treatment of patients with CNS tumors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-1109790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-1460426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-2809683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-325299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-3872167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-6165811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-7435141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-7540653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-7703440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-8011285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-8097319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-8161884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-8551233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-8551239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-8551248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-8609412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-8610141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-8760800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-8816812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-9079797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9314567-9096653
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1177-82
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9314567-Animals,
pubmed-meshheading:9314567-Bone Marrow Cells,
pubmed-meshheading:9314567-Cancer Vaccines,
pubmed-meshheading:9314567-Cell Extracts,
pubmed-meshheading:9314567-Central Nervous System Neoplasms,
pubmed-meshheading:9314567-Dendritic Cells,
pubmed-meshheading:9314567-Histocytochemistry,
pubmed-meshheading:9314567-Immunotherapy,
pubmed-meshheading:9314567-Melanoma, Experimental,
pubmed-meshheading:9314567-Mice,
pubmed-meshheading:9314567-RNA, Neoplasm,
pubmed-meshheading:9314567-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:9314567-Tumor Cells, Cultured
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pubmed:year |
1997
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pubmed:articleTitle |
Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors.
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pubmed:affiliation |
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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