Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1997-10-30
|
| pubmed:abstractText |
Although the shortest (class I) minisatellite (i.e., variable number of tandem repeats [VNTR]) alleles in the 5' region of the insulin gene are positively associated with IDDM in Caucasians, the majority of Japanese are homozygous for class I alleles. Here, we determined the exact length, in number of repeat units (RUs), of class I alleles in Japanese subjects. The distribution of class I alleles in Japanese was trimodal, with peaks located at 32/33, 41, and 44 RUs. The shortest component (i.e., 1S [25-38 RUs]) alleles were significantly increased in the IDDM group compared with the control group (54 vs. 46%; P = 0.040). The 1S/1S genotype was significantly increased in the IDDM patients (34 vs. 20%; P = 0.005; relative risk 2.1). Furthermore, the transmission disequilibrium test of Japanese families with 1S/1M or 1S/1L heterozygous parents confirmed the association of 1S alleles; 17 alleles of 1S and 6 alleles of 1M (39-41 RUs) or 1L (42-44 RUs) were transmitted to affected offspring (P = 0.022). In addition, we found tight linkage of 1S with allele 9 of the tyrosine hydroxylase gene microsatellite and allele (-) of the IGF-II gene Apa I polymorphism, but neither 9 nor (-) alleles were significantly associated with IDDM. The present study suggests that a class I subset may have a role in IDDM susceptibility in Japan. It was revealed that the difference between 1S alleles and 1M or 1L alleles is almost consistently characterized by a sequence variation generated by deletion of two copies of an ACAGGGGTCC CGGGG repeat element, implying that sequence variation of class I alleles may influence disease susceptibility.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1637-42
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9313762-Adolescent,
pubmed-meshheading:9313762-Adult,
pubmed-meshheading:9313762-Aged,
pubmed-meshheading:9313762-Alleles,
pubmed-meshheading:9313762-Base Sequence,
pubmed-meshheading:9313762-Child,
pubmed-meshheading:9313762-Child, Preschool,
pubmed-meshheading:9313762-Diabetes Mellitus, Type 1,
pubmed-meshheading:9313762-Gene Frequency,
pubmed-meshheading:9313762-Genotype,
pubmed-meshheading:9313762-Humans,
pubmed-meshheading:9313762-Insulin,
pubmed-meshheading:9313762-Insulin-Like Growth Factor II,
pubmed-meshheading:9313762-Japan,
pubmed-meshheading:9313762-Middle Aged,
pubmed-meshheading:9313762-Minisatellite Repeats,
pubmed-meshheading:9313762-Polymerase Chain Reaction,
pubmed-meshheading:9313762-Tyrosine 3-Monooxygenase
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population.
|
| pubmed:affiliation |
Fourth Department of Internal Medicine, Saitama Medical School, Japan. awata@saitama-med.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|