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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
3
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|
pubmed:dateCreated |
1997-10-23
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|
pubmed:abstractText |
Isoprostanes are products of free radical-catalyzed peroxidation and 8-epi-prostaglandin (PG) F2 alpha is the most important vasomodulator of this group of compounds. In human lower leg lymphatics isolated from 5 different patients without a smoking history or hyperlipidemia, 8-epi-PGF2 alpha stimulated in vitro contraction more strongly than the thromboxane receptor agonist U46619. Other isoprostanes (8-epi-PGE1, 8-epi-PGE2) had only limited lymphatic contractile potency. These data suggest a potentially relevant role for epi-8-PGF2 alpha in facilitating lymph transport especially in conditions of inflammation.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Sep
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|
pubmed:issn |
0024-7766
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9313207-15-Hydroxy-11 alpha,9...,
pubmed-meshheading:9313207-Adolescent,
pubmed-meshheading:9313207-Adult,
pubmed-meshheading:9313207-Dinoprost,
pubmed-meshheading:9313207-Female,
pubmed-meshheading:9313207-Humans,
pubmed-meshheading:9313207-Lymphatic System,
pubmed-meshheading:9313207-Male,
pubmed-meshheading:9313207-Middle Aged,
pubmed-meshheading:9313207-Prostaglandin Endoperoxides, Synthetic,
pubmed-meshheading:9313207-Thromboxane A2,
pubmed-meshheading:9313207-Vasoconstrictor Agents
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pubmed:year |
1997
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|
pubmed:articleTitle |
Isoprostane 8-epi-prostaglandin F2 alpha is a potent contractor of human peripheral lymphatics.
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pubmed:affiliation |
Department of Nuclear Medicine, University of Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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