Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1997-10-29
pubmed:abstractText
Maternal protein restriction is a model of fetal programming of adult glucose intolerance. Perfused livers of 48-h- starved adult offspring of rat dams fed 8% protein diets during pregnancy and lactation produced more glucose from 6 mM lactate than did control livers from rats whose dams were fed 20% protein. In control livers, a mean of 24% of the glucose formed from lactate in the periportal region of the lobule was taken up by the most distal perivenous cells; this distal perivenous uptake was greatly diminished in maternal low protein (MLP) livers, accounting for a major fraction of the increased glucose output of MLP livers. In control livers, the distal perivenous cells contained 40% of the total glucokinase of the liver; this perivenous concentration of glucokinase was greatly reduced in MLP livers. Intralobular distribution of phosphenolpyruvate carboxykinase was unaltered, though overall increased activity could have contributed to the elevated glucose output. Hepatic lobular volume in MLP livers was twice that in control livers, indicating that MLP livers had half the normal number of lobules. Fetal programming of adult glucose metabolism may operate partly through structural alterations and changes in glucokinase expression in the immediate perivenous region.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-1017801, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-1570017, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-1644236, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-1898360, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-2178691, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-2203828, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-2865284, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-3010376, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-3813560, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-3977871, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-5564306, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-5776547, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-6027238, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-6049928, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-6545673, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-7665557, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-7672362, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-7729787, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-7851536, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-8020491, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-8100248, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-8373368, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-8515054, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-8720607, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-8736760, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-8912670, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-8942365, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-8945470, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-8945471, http://linkedlifedata.com/resource/pubmed/commentcorrection/9312176-9176217
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1768-74
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation.
pubmed:affiliation
Cellular Mechanisms Research Group, Medical Unit, St. Bartholomew's and the Royal London Hospital School of Medicine and Dentistry, London, United Kingdom. s.p.burns@mds.qmw.ac.uk
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't