| pubmed-article:9312122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9312122 | lifeskim:mentions | umls-concept:C0087140 | lld:lifeskim |
| pubmed-article:9312122 | lifeskim:mentions | umls-concept:C0010853 | lld:lifeskim |
| pubmed-article:9312122 | lifeskim:mentions | umls-concept:C0389995 | lld:lifeskim |
| pubmed-article:9312122 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:9312122 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:9312122 | lifeskim:mentions | umls-concept:C0969709 | lld:lifeskim |
| pubmed-article:9312122 | pubmed:issue | 40 | lld:pubmed |
| pubmed-article:9312122 | pubmed:dateCreated | 1997-10-22 | lld:pubmed |
| pubmed-article:9312122 | pubmed:abstractText | The small GTPase Rho is implicated in cytoskeletal rearrangements including stress fiber and focal adhesion formation and in the transcriptional activation of c-fos serum response element. In vitro, Rho-kinase, which is activated by Rho, phosphorylates not only myosin light chain (MLC) (thereby activating myosin ATPase) but also myosin phosphatase, thus inactivating myosin phosphatase. Rho-kinase is involved in the formation of stress fibers and focal adhesions in fibroblasts. Here we show that the expression of constitutively active Rho-kinase increased the level of MLC phosphorylation. The activity of Rho-kinase was necessary for maintaining the vinculin-containing focal adhesions, whereas organized actin stress fibers were not necessary for this. The microinjection of constitutively active Rho-kinase into fibroblasts induced the formation of focal adhesions to some extent under the conditions where organized actin stress fibers were disrupted. The expression of constitutively active Rho-kinase also stimulated the transcriptional activity of c-fos serum response element. These results suggest that Rho-kinase has distinct roles in divergent pathways downstream of Rho, which include MLC phosphorylation leading to stress fiber formation, focal adhesion formation, and gene expression. | lld:pubmed |
| pubmed-article:9312122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9312122 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9312122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9312122 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9312122 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9312122 | pubmed:author | pubmed-author:TokuiTT | lld:pubmed |
| pubmed-article:9312122 | pubmed:author | pubmed-author:NakamuraNN | lld:pubmed |
| pubmed-article:9312122 | pubmed:author | pubmed-author:ChiharaKK | lld:pubmed |
| pubmed-article:9312122 | pubmed:author | pubmed-author:IkebeMM | lld:pubmed |
| pubmed-article:9312122 | pubmed:author | pubmed-author:IchikawaHH | lld:pubmed |
| pubmed-article:9312122 | pubmed:author | pubmed-author:ShibataMM | lld:pubmed |
| pubmed-article:9312122 | pubmed:author | pubmed-author:YanoTT | lld:pubmed |
| pubmed-article:9312122 | pubmed:author | pubmed-author:AmanoMM | lld:pubmed |
| pubmed-article:9312122 | pubmed:author | pubmed-author:KaibuchiKK | lld:pubmed |
| pubmed-article:9312122 | pubmed:author | pubmed-author:IkebeRR | lld:pubmed |
| pubmed-article:9312122 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9312122 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:9312122 | pubmed:volume | 272 | lld:pubmed |
| pubmed-article:9312122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9312122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9312122 | pubmed:pagination | 25121-7 | lld:pubmed |
| pubmed-article:9312122 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:meshHeading | pubmed-meshheading:9312122-... | lld:pubmed |
| pubmed-article:9312122 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9312122 | pubmed:articleTitle | Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase. | lld:pubmed |
| pubmed-article:9312122 | pubmed:affiliation | Division of Signal Transduction, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-01, Japan. | lld:pubmed |
| pubmed-article:9312122 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9312122 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9312122 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9312122 | lld:pubmed |
