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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
40
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pubmed:dateCreated |
1997-10-22
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pubmed:abstractText |
Several lines of evidence suggest that accumulation of cytoplasmic beta-catenin transduces an oncogenic signal. We show that beta-catenin is ubiquitinated and degraded by the proteosome and that beta-catenin stability is regulated by a diacylglycerol-independent protein kinase C-like kinase activity, which is required for beta-catenin ubiquitination. We also define a six-amino acid sequence found in both beta-catenin and the NF-kappaB regulatory protein IkappaBalpha, which, upon phosphorylation, targets both proteins for ubiquitination. Mutation of a single serine within the ubiquitination targeting sequence prevents ubiquitination of beta-catenin. Mutations within the ubiquitination targeting sequence of beta-catenin may be oncogenic.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Maleimides,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoserine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/bisindolylmaleimide I,
http://linkedlifedata.com/resource/pubmed/chemical/calphostin C
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
272
|
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
24735-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9312064-Amino Acid Sequence,
pubmed-meshheading:9312064-Consensus Sequence,
pubmed-meshheading:9312064-Cytoskeletal Proteins,
pubmed-meshheading:9312064-DNA-Binding Proteins,
pubmed-meshheading:9312064-Enzyme Inhibitors,
pubmed-meshheading:9312064-Humans,
pubmed-meshheading:9312064-I-kappa B Proteins,
pubmed-meshheading:9312064-Indoles,
pubmed-meshheading:9312064-Maleimides,
pubmed-meshheading:9312064-Molecular Sequence Data,
pubmed-meshheading:9312064-Mutagenesis, Site-Directed,
pubmed-meshheading:9312064-NF-kappa B,
pubmed-meshheading:9312064-Naphthalenes,
pubmed-meshheading:9312064-Phosphorylation,
pubmed-meshheading:9312064-Phosphoserine,
pubmed-meshheading:9312064-Point Mutation,
pubmed-meshheading:9312064-Protein Kinase C,
pubmed-meshheading:9312064-Protein Processing, Post-Translational,
pubmed-meshheading:9312064-Sequence Alignment,
pubmed-meshheading:9312064-Serine,
pubmed-meshheading:9312064-Substrate Specificity,
pubmed-meshheading:9312064-Tetradecanoylphorbol Acetate,
pubmed-meshheading:9312064-Trans-Activators,
pubmed-meshheading:9312064-Ubiquitins,
pubmed-meshheading:9312064-beta Catenin
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pubmed:year |
1997
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pubmed:articleTitle |
Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin.
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pubmed:affiliation |
Lombardi Cancer Center, Georgetown University Medical Center, Washington, D. C. 20007, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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