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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5335
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pubmed:dateCreated |
1997-10-23
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pubmed:abstractText |
The inhibitory gamma-aminobutyric acid-containing (GABAergic) neurons of the thalamic reticular and perigeniculate nuclei are involved in the generation of normal and abnormal synchronized activity in thalamocortical networks. An important factor controlling the generation of activity in this system is the amplitude and duration of inhibitory postsynaptic potentials (IPSPs) in thalamocortical cells, which depend on the pattern of activity generated in thalamic reticular and perigeniculate cells. Activation of single ferret perigeniculate neurons generated three distinct patterns of GABAergic IPSPs in thalamocortical neurons of the dorsal lateral geniculate nucleus: Low-frequency tonic discharge resulted in small-amplitude IPSPs mediated by GABAA receptors, burst firing resulted in large-amplitude GABAA IPSPs, and prolonged burst firing activated IPSPs mediated by GABAA and GABAB receptors. These functional properties of GABAergic inhibition can reconfigure the operations of thalamocortical networks into patterns of activity associated with waking, slow-wave sleep, and generalized seizures.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bicuculline,
http://linkedlifedata.com/resource/pubmed/chemical/CGP 35348,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Lysine,
http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, GABA-B,
http://linkedlifedata.com/resource/pubmed/chemical/bicuculline methiodide,
http://linkedlifedata.com/resource/pubmed/chemical/biocytin,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
278
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
130-4
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:9311919-Action Potentials,
pubmed-meshheading:9311919-Animals,
pubmed-meshheading:9311919-Bicuculline,
pubmed-meshheading:9311919-Dendrites,
pubmed-meshheading:9311919-Ferrets,
pubmed-meshheading:9311919-GABA Agonists,
pubmed-meshheading:9311919-GABA Antagonists,
pubmed-meshheading:9311919-Geniculate Bodies,
pubmed-meshheading:9311919-Glutamic Acid,
pubmed-meshheading:9311919-Lysine,
pubmed-meshheading:9311919-Neurons,
pubmed-meshheading:9311919-Organophosphorus Compounds,
pubmed-meshheading:9311919-Patch-Clamp Techniques,
pubmed-meshheading:9311919-Presynaptic Terminals,
pubmed-meshheading:9311919-Receptors, GABA-A,
pubmed-meshheading:9311919-Receptors, GABA-B,
pubmed-meshheading:9311919-Synaptic Transmission,
pubmed-meshheading:9311919-Thalamic Nuclei,
pubmed-meshheading:9311919-gamma-Aminobutyric Acid
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pubmed:year |
1997
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pubmed:articleTitle |
Functional dynamics of GABAergic inhibition in the thalamus.
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pubmed:affiliation |
Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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