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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0018381,
umls-concept:C0018787,
umls-concept:C0023206,
umls-concept:C0024432,
umls-concept:C0026336,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035015,
umls-concept:C0063041,
umls-concept:C0205263,
umls-concept:C0205421,
umls-concept:C0282552,
umls-concept:C0284559,
umls-concept:C0301625,
umls-concept:C0522537,
umls-concept:C0871261,
umls-concept:C1280500,
umls-concept:C1548437,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882923,
umls-concept:C2911692
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pubmed:issue |
5
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pubmed:dateCreated |
1997-10-14
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pubmed:abstractText |
If complement (C) activation is prevented or the host is C depleted, discordant vascularized xenografts undergo delayed xenograft rejection (DXR), characterized by graft infiltration by macrophages (MO) and natural killer (NK) cells, endothelial cell activation, and widespread fibrin deposition. Given a lack of effect of T cell-directed therapies on development of DXR, we evaluated two novel agents, 15-deoxyspergualin (DSG) and leflunomide (LEF), with reported anti-B-cell and/or anti-MO actions.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Complement System Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Isoxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/anti-IgM,
http://linkedlifedata.com/resource/pubmed/chemical/gusperimus,
http://linkedlifedata.com/resource/pubmed/chemical/leflunomide
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
696-704
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9311705-Animals,
pubmed-meshheading:9311705-Antibodies, Anti-Idiotypic,
pubmed-meshheading:9311705-Antibodies, Monoclonal,
pubmed-meshheading:9311705-Antibody Formation,
pubmed-meshheading:9311705-B-Lymphocytes,
pubmed-meshheading:9311705-Chemokine CCL2,
pubmed-meshheading:9311705-Chemokines,
pubmed-meshheading:9311705-Complement System Proteins,
pubmed-meshheading:9311705-Graft Rejection,
pubmed-meshheading:9311705-Graft Survival,
pubmed-meshheading:9311705-Guanidines,
pubmed-meshheading:9311705-Guinea Pigs,
pubmed-meshheading:9311705-Heart Transplantation,
pubmed-meshheading:9311705-Immunoglobulin M,
pubmed-meshheading:9311705-Immunosuppressive Agents,
pubmed-meshheading:9311705-Isoxazoles,
pubmed-meshheading:9311705-Lectins,
pubmed-meshheading:9311705-Macrophage Activation,
pubmed-meshheading:9311705-Macrophages,
pubmed-meshheading:9311705-Male,
pubmed-meshheading:9311705-Rats,
pubmed-meshheading:9311705-Rats, Inbred BN,
pubmed-meshheading:9311705-Rats, Inbred Lew,
pubmed-meshheading:9311705-Rats, Sprague-Dawley,
pubmed-meshheading:9311705-Transplantation, Heterologous,
pubmed-meshheading:9311705-Transplantation, Homologous
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pubmed:year |
1997
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pubmed:articleTitle |
Effects of leflunomide and deoxyspergualin in the guinea pig-->rat cardiac model of delayed xenograft rejection: suppression of B cell and C-C chemokine responses but not induction of macrophage lectin.
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pubmed:affiliation |
Sandoz Center for Immunobiology and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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