| pubmed-article:9311577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9311577 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9311577 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9311577 | lifeskim:mentions | umls-concept:C0018120 | lld:lifeskim |
| pubmed-article:9311577 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:9311577 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:9311577 | lifeskim:mentions | umls-concept:C0870078 | lld:lifeskim |
| pubmed-article:9311577 | lifeskim:mentions | umls-concept:C0750480 | lld:lifeskim |
| pubmed-article:9311577 | lifeskim:mentions | umls-concept:C1514863 | lld:lifeskim |
| pubmed-article:9311577 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9311577 | pubmed:dateCreated | 1997-10-23 | lld:pubmed |
| pubmed-article:9311577 | pubmed:abstractText | Different ovarian follicle counting procedures were investigated to reduce labor while retaining statistical power. Intact ovaries of untreated CD-1 mice (20/group) from National Toxicology Program Reproductive Assessment by Continuous Breeding (RACB) studies were serially sectioned at 6 microm. Mean numbers of small and growing follicles were used to assess sampling efficiency. In 10 mice per group, comparisons were made between 10% nonrandom samples from every 10th section starting at either the first or sixth section having follicles (approximately 40 sections per ovary). These 10% counts were compared with 5% (20 sections) and 20% (80 sections) nonrandom samples and with 1% (4 sections), 5%, or 10% random samples from the same 10 animals. For two studies, a 10% nonrandom sample was analyzed from 20 mice per group. Follicle counts for each group were comparable regardless of the sampling paradigm. Four to 10 animals provided 90% confidence that a 20% difference in mean counts would be detected. The 1% sample had a larger error term and, thus, slightly reduced statistical power. These data suggest that follicle counts from 1% or 5% random samples may provide a suitable screen for ovarian toxicity. | lld:pubmed |
| pubmed-article:9311577 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9311577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9311577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9311577 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9311577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9311577 | pubmed:issn | 0890-6238 | lld:pubmed |
| pubmed-article:9311577 | pubmed:author | pubmed-author:ChenJ JJJ | lld:pubmed |
| pubmed-article:9311577 | pubmed:author | pubmed-author:HeindelJ JJJ | lld:pubmed |
| pubmed-article:9311577 | pubmed:author | pubmed-author:BucciT JTJ | lld:pubmed |
| pubmed-article:9311577 | pubmed:author | pubmed-author:BolonBB | lld:pubmed |
| pubmed-article:9311577 | pubmed:author | pubmed-author:WarbrittonA... | lld:pubmed |
| pubmed-article:9311577 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9311577 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:9311577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9311577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9311577 | pubmed:pagination | 689-96 | lld:pubmed |
| pubmed-article:9311577 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:meshHeading | pubmed-meshheading:9311577-... | lld:pubmed |
| pubmed-article:9311577 | pubmed:articleTitle | Influence of sampling on the reproducibility of ovarian follicle counts in mouse toxicity studies. | lld:pubmed |
| pubmed-article:9311577 | pubmed:affiliation | Pathology Associates International (an SAIC Company), National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. | lld:pubmed |
| pubmed-article:9311577 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9311577 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9311577 | lld:pubmed |
