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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1997-11-6
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pubmed:abstractText |
Plasticity at the neuronal level commonly involves use-dependent changes in strength of particular synaptic pathways or regulation of postsynaptic properties by modulatory transmitters. Here we analyze a novel form of short-term plasticity mediated by use-dependent facilitation of postsynaptic responsiveness. Using current- and voltage-clamp recordings, we found that all spinal ventral horn neurons able to generate plateau potentials showed depolarization-induced facilitation of the underlying inward current. Facilitation was noticeable when the neurons were depolarized to more than -50 mV at intervals <4 s. When stimulation with fast triangular voltage ramps was used, the inward current activated at a less depolarized potential during the second ramp. The inward current and facilitation was eliminated by nifedipine, a selective antagonist of L-type calcium channels. Depolarization-induced facilitation of low-voltage-activated L-type calcium channels is suggested to be the underlying mechanism. It is noted that facilitation occurs on a time scale compatible with a role in phasic motor activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarine,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Antagonists
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-3077
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1740-2
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9310460-Animals,
pubmed-meshheading:9310460-Anterior Horn Cells,
pubmed-meshheading:9310460-Calcium Channel Blockers,
pubmed-meshheading:9310460-Electrophysiology,
pubmed-meshheading:9310460-Interneurons,
pubmed-meshheading:9310460-Ion Channels,
pubmed-meshheading:9310460-Motor Neurons,
pubmed-meshheading:9310460-Muscarine,
pubmed-meshheading:9310460-Muscarinic Agonists,
pubmed-meshheading:9310460-Muscarinic Antagonists,
pubmed-meshheading:9310460-Neuronal Plasticity,
pubmed-meshheading:9310460-Patch-Clamp Techniques,
pubmed-meshheading:9310460-Spinal Cord,
pubmed-meshheading:9310460-Turtles
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pubmed:year |
1997
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pubmed:articleTitle |
Depolarization-induced facilitation of a plateau-generating current in ventral horn neurons in the turtle spinal cord.
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pubmed:affiliation |
Laboratory of Neurophysiology, Biomedical Research Institute, Kaunas Medical Academy, Lithuania.
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pubmed:publicationType |
Journal Article,
In Vitro
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