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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-10-21
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pubmed:abstractText |
The value of intratumoral thymidylate synthase (TS) quantitation as a predictive parameter for hepatic artery infusion (HAI) chemotherapy in patients with colorectal liver metastases was investigated. Relative TS mRNA levels were determined in 29 tumor samples using a quantitative RT-PCR amplification method. The median level of expression was 3.0 x 10(-3) (no units) and varied considerably among the tumors over a range of 135-fold. Patients with low TS levels were 4.1-fold more likely to respond (P < 0.03) compared to patients with high TS levels. Our results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Epirubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Floxuridine,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil,
http://linkedlifedata.com/resource/pubmed/chemical/Leucovorin,
http://linkedlifedata.com/resource/pubmed/chemical/Mitoxantrone,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidylate Synthase
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0304-3835
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pubmed:author |
pubmed-author:BegerH GHG,
pubmed-author:ButzerUU,
pubmed-author:DanenbergK DKD,
pubmed-author:DanenbergP VPV,
pubmed-author:KornmannMM,
pubmed-author:LederG HGH,
pubmed-author:LinkK HKH,
pubmed-author:LvovY MYM,
pubmed-author:MetzgerRR,
pubmed-author:PillaschJJ,
pubmed-author:ROSEW AWA,
pubmed-author:WeindelMM
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-35
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9310257-Adult,
pubmed-meshheading:9310257-Aged,
pubmed-meshheading:9310257-Antimetabolites, Antineoplastic,
pubmed-meshheading:9310257-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9310257-Biological Markers,
pubmed-meshheading:9310257-Colorectal Neoplasms,
pubmed-meshheading:9310257-Drug Administration Schedule,
pubmed-meshheading:9310257-Drug Resistance, Neoplasm,
pubmed-meshheading:9310257-Epirubicin,
pubmed-meshheading:9310257-Female,
pubmed-meshheading:9310257-Floxuridine,
pubmed-meshheading:9310257-Fluorouracil,
pubmed-meshheading:9310257-Hepatic Artery,
pubmed-meshheading:9310257-Humans,
pubmed-meshheading:9310257-Infusions, Intra-Arterial,
pubmed-meshheading:9310257-Leucovorin,
pubmed-meshheading:9310257-Liver Neoplasms,
pubmed-meshheading:9310257-Male,
pubmed-meshheading:9310257-Middle Aged,
pubmed-meshheading:9310257-Mitoxantrone,
pubmed-meshheading:9310257-Polymerase Chain Reaction,
pubmed-meshheading:9310257-Predictive Value of Tests,
pubmed-meshheading:9310257-Prognosis,
pubmed-meshheading:9310257-RNA, Messenger,
pubmed-meshheading:9310257-Survival Rate,
pubmed-meshheading:9310257-Thymidylate Synthase,
pubmed-meshheading:9310257-Transcription, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy.
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pubmed:affiliation |
Department of General Surgery, University of Ulm, Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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