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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-10-22
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pubmed:abstractText |
Thrombosis after arterial injury is often initiated by von Willebrand factor (vWF)-dependent platelet accumulation. A promising antithrombotic strategy is the interruption of platelet/vWF interactions. Previously, we demonstrated how chemical and affinity modification can enhance heparin's anti-vWF activity while reducing conventional anticoagulation. Here, we investigated whether a modified heparin can block platelet-dominated arterial thrombosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0741-5214
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
366-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9308582-Animals,
pubmed-meshheading:9308582-Antibodies, Monoclonal,
pubmed-meshheading:9308582-Anticoagulants,
pubmed-meshheading:9308582-Carotid Artery Injuries,
pubmed-meshheading:9308582-Carotid Artery Thrombosis,
pubmed-meshheading:9308582-Disease Models, Animal,
pubmed-meshheading:9308582-Drug Evaluation, Preclinical,
pubmed-meshheading:9308582-Guinea Pigs,
pubmed-meshheading:9308582-Hemostasis,
pubmed-meshheading:9308582-Heparin,
pubmed-meshheading:9308582-Male,
pubmed-meshheading:9308582-Platelet Aggregation Inhibitors,
pubmed-meshheading:9308582-Recurrence,
pubmed-meshheading:9308582-von Willebrand Factor
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pubmed:year |
1997
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|
pubmed:articleTitle |
Prevention of arterial thrombosis using a novel heparin with enhanced antiplatelet activity and reduced anticoagulant activity.
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pubmed:affiliation |
Division of Vascular Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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