Linked Life Data

9307936

Source:http://linkedlifedata.com/resource/pubmed/id/9307936

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1998-1-6
pubmed:abstractText
The effects of partially hydrolyzed, nonviscous, guar gum (PHGG) on cholesterol metabolism and digestive balance have been compared with those of native guar gum (GUAR) in rats adapted to 0.4% cholesterol diets. Both types of guar gum elicited acidic fermentations in the large intestine, but only GUAR effectively lowered plasma cholesterol (P < 0.001), chiefly in the triglyceride-rich lipoprotein fraction. The biliary bile acid excretion was significantly enhanced in rats fed GUAR (P < 0.05), as well as the intestinal and cecal bile acid pool (P < 0.001). In rats fed GUAR and to a lesser extent in those fed PHGG, the fecal excretion of bile acids and neutral sterol was higher than in controls (P < 0.01). The digestive balance (cholesterol intake-steroid excretion) was positive in control rats (+47 mumol/d), whereas it was negative in rats fed GUAR (-20 mumol/d), which could involve a higher rate of endogenous cholesterol synthesis. In rats fed PHGG, the steroid balance remained slightly positive. Liver 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity was very low (22 pmol/min/mg protein), owing to cholesterol supplementation, in control rats or in rats fed PHGG, whereas it was markedly higher (+463%) in rats fed GUAR. In conclusion, even if PHGG does alter some parameters of the enterohepatic cycle of cholesterol and bile acids, its effects are not sufficient to elicit a significant cholesterol-lowering effect. The intestinal (ileal or cecal) reabsorption of bile acids was not reduced, but rather increased, by GUAR; nevertheless the intestinal capacities of reabsorption were overwhelmed by the enlargement of the digestive pool of bile acids. In the present model, induction of HMG-CoA reductase probably takes place in the presence of elevated portal bile acid concentrations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0024-4201
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
953-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9307936-Animals, pubmed-meshheading:9307936-Anticholesteremic Agents, pubmed-meshheading:9307936-Bile, pubmed-meshheading:9307936-Bile Acids and Salts, pubmed-meshheading:9307936-Body Weight, pubmed-meshheading:9307936-Cecum, pubmed-meshheading:9307936-Cholesterol, pubmed-meshheading:9307936-Dietary Fats, pubmed-meshheading:9307936-Feces, pubmed-meshheading:9307936-Galactans, pubmed-meshheading:9307936-Hydrogen-Ion Concentration, pubmed-meshheading:9307936-Hydroxymethylglutaryl CoA Reductases, pubmed-meshheading:9307936-Intestinal Absorption, pubmed-meshheading:9307936-Lipids, pubmed-meshheading:9307936-Lipoproteins, pubmed-meshheading:9307936-Liver, pubmed-meshheading:9307936-Male, pubmed-meshheading:9307936-Mannans, pubmed-meshheading:9307936-Organ Size, pubmed-meshheading:9307936-Plant Gums, pubmed-meshheading:9307936-Rats, pubmed-meshheading:9307936-Rats, Wistar
pubmed:year
1997
pubmed:articleTitle
The cholesterol-lowering effect of guar gum is not the result of a simple diversion of bile acids toward fecal excretion.
pubmed:affiliation
Laboratoire des Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix, Ceyrat, France.
pubmed:publicationType
Journal Article