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pubmed-article:9307927pubmed:abstractTextCase histories of autistic twins with absence seizures are presented. The boys had autistic features prior to the onset of seizures during their second year of life. By age 3 years, the twins were significantly delayed in the areas of socialization, communications and impulse control. Typical autistic features were pronounced, including perseverative, nonpurposeful and self-stimulatory behaviors; lack of symbolic play; poor eye contact; echolalic and noncommunicative speech; and unresponsiveness to disciplinary efforts. The absence seizures, although first observed by the parents early in the twins' second year, were not diagnosed until age 3 years 1 month. The seizures consisted of 50-60 staring spells per day. Both boys responded to valproic acid treatment with control of their seizures and with a dramatically accelerated rate of acquisition of both language and social skills. A possible causal relationship between autism and absence seizures in these children is explored.lld:pubmed
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pubmed-article:9307927pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:9307927pubmed:year1997lld:pubmed
pubmed-article:9307927pubmed:articleTitleValproic acid treatment of epilepsy in autistic twins.lld:pubmed
pubmed-article:9307927pubmed:affiliationDuPont Hospital for Children, Wilmington, Delaware, 19899, USA.lld:pubmed
pubmed-article:9307927pubmed:publicationTypeJournal Articlelld:pubmed
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