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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1997-11-13
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pubmed:abstractText |
Case histories of autistic twins with absence seizures are presented. The boys had autistic features prior to the onset of seizures during their second year of life. By age 3 years, the twins were significantly delayed in the areas of socialization, communications and impulse control. Typical autistic features were pronounced, including perseverative, nonpurposeful and self-stimulatory behaviors; lack of symbolic play; poor eye contact; echolalic and noncommunicative speech; and unresponsiveness to disciplinary efforts. The absence seizures, although first observed by the parents early in the twins' second year, were not diagnosed until age 3 years 1 month. The seizures consisted of 50-60 staring spells per day. Both boys responded to valproic acid treatment with control of their seizures and with a dramatically accelerated rate of acquisition of both language and social skills. A possible causal relationship between autism and absence seizures in these children is explored.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0888-0395
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
244-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9307927-Anticonvulsants,
pubmed-meshheading:9307927-Autistic Disorder,
pubmed-meshheading:9307927-Child, Preschool,
pubmed-meshheading:9307927-Developmental Disabilities,
pubmed-meshheading:9307927-Diseases in Twins,
pubmed-meshheading:9307927-Epilepsy, Absence,
pubmed-meshheading:9307927-Follow-Up Studies,
pubmed-meshheading:9307927-Humans,
pubmed-meshheading:9307927-Male,
pubmed-meshheading:9307927-Twins, Monozygotic,
pubmed-meshheading:9307927-Valproic Acid
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pubmed:year |
1997
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pubmed:articleTitle |
Valproic acid treatment of epilepsy in autistic twins.
|
pubmed:affiliation |
DuPont Hospital for Children, Wilmington, Delaware, 19899, USA.
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pubmed:publicationType |
Journal Article,
Case Reports
|