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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1997-9-25
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pubmed:abstractText |
The sialic acid analogue zanamivir (GG167) is a selective inhibitor of influenza A and B virus neuraminidases. These viral enzymes are essential for the release of virus from infected cells, and they may also reduce the inactivation of virus by respiratory secretions. When administered experimentally directly to the respiratory tract, zanamivir has potent antiviral effects. We assessed the therapeutic activity of zanamivir in adults with acute influenza.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0028-4793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
337
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
874-80
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:9302301-Administration, Inhalation,
pubmed-meshheading:9302301-Administration, Intranasal,
pubmed-meshheading:9302301-Adolescent,
pubmed-meshheading:9302301-Adult,
pubmed-meshheading:9302301-Antiviral Agents,
pubmed-meshheading:9302301-Double-Blind Method,
pubmed-meshheading:9302301-Enzyme Inhibitors,
pubmed-meshheading:9302301-Guanidines,
pubmed-meshheading:9302301-Humans,
pubmed-meshheading:9302301-Influenza, Human,
pubmed-meshheading:9302301-Influenza A virus,
pubmed-meshheading:9302301-Influenza B virus,
pubmed-meshheading:9302301-Neuraminidase,
pubmed-meshheading:9302301-Nose,
pubmed-meshheading:9302301-Pyrans,
pubmed-meshheading:9302301-Sialic Acids,
pubmed-meshheading:9302301-Time Factors,
pubmed-meshheading:9302301-Treatment Outcome,
pubmed-meshheading:9302301-Zanamivir
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pubmed:year |
1997
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pubmed:articleTitle |
Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. GG167 Influenza Study Group.
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pubmed:affiliation |
University of Virginia, Charlottesville 22908, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Multicenter Study
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