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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-10-15
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pubmed:abstractText |
Oxidized low-density lipoprotein (Ox-LDL) has been implicated in the attenuated endothelium-dependent vasodilatation in atherosclerotic arteries and, possibly, in hypertension. The aim of the present study was to investigate gene expression of recently-identified endothelial Ox-LDL receptor (LOX-1) in hypertensive state. SHR-SP, WKY, Dahl salt-sensitive (DS) and salt-resistant rats (DR) were fed salt-loaded or control diet. RNA was extracted from the aorta and vein. LOX-1 expression was examined by Northern blotting. LOX-1 mRNA was low in the aorta and vein of WKY, whereas it was markedly upregulated in those of SHR-SP. LOX-1 expression was low in the aorta of DR on both diets and of DS on a control diet, whereas it was elevated in that of salt-loaded DS. These results indicated that LOX-1 expression in the aorta and vein was upregulated in hypertensive rats, which may be involved in the impaired endothelium-dependent vasodilation in these rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Oldlr1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Oxidized LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class E,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium, Dietary
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
237
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
496-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9299391-Animals,
pubmed-meshheading:9299391-Aorta,
pubmed-meshheading:9299391-Blood Pressure,
pubmed-meshheading:9299391-DNA Primers,
pubmed-meshheading:9299391-Endothelium, Vascular,
pubmed-meshheading:9299391-Hypertension,
pubmed-meshheading:9299391-Male,
pubmed-meshheading:9299391-Organ Specificity,
pubmed-meshheading:9299391-Polymerase Chain Reaction,
pubmed-meshheading:9299391-RNA, Messenger,
pubmed-meshheading:9299391-Rats,
pubmed-meshheading:9299391-Rats, Inbred SHR,
pubmed-meshheading:9299391-Rats, Inbred Strains,
pubmed-meshheading:9299391-Rats, Inbred WKY,
pubmed-meshheading:9299391-Receptors, LDL,
pubmed-meshheading:9299391-Receptors, Oxidized LDL,
pubmed-meshheading:9299391-Scavenger Receptors, Class E,
pubmed-meshheading:9299391-Sodium, Dietary,
pubmed-meshheading:9299391-Species Specificity,
pubmed-meshheading:9299391-Transcription, Genetic,
pubmed-meshheading:9299391-Veins
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pubmed:year |
1997
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pubmed:articleTitle |
Enhanced expression of endothelial oxidized low-density lipoprotein receptor (LOX-1) in hypertensive rats.
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pubmed:affiliation |
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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