Linked Life Data

9296449

Source:http://linkedlifedata.com/resource/pubmed/id/9296449

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-10-20
pubmed:abstractText
Captopril ([2S]-1-[3-mercapto-2-methyl-propionyl]-L-proline) was found to protect erythrocytes from hemolysis caused by 2,2'-azobis (2-amidinopropane) (AAPH) and hypochlorite, erythrocyte membranes from lipid peroxidation caused by tert-butyl hydroperoxide (tBOOH) and hypochlorite, erythrocyte membrane ATPases from inactivation caused by tBOOH and hemoglobin from oxidation caused by AAPH and tBOOH. In all these systems enalapril ([S]-1-[N-(1-[ethoxycarbonyl]-3-phenylpropyl)-L-alanyl]-L-proline) was not protective or even increased the damage, especially with hypochlorite, probably due to chloramine formation. Captopril but not enalapril inhibited ascorbate autoxidation caused by Cu2+, which indicates that captopril binds Cu2+. On the other hand, deoxyribose degradation caused by iron and copper ions and DNA damage by o-phenanthroline/Cu2+/H2O2/beta-mercaptoethanol was enhanced by both captopril and enalapril. The effect of captopril was usually higher, apparently due to the reducing properties of captopril, which could reduce metal ions enabling their participation in the Fenton reaction. These results indicate that only -SH-group-containing inhibitors of angiotensin-converting enzyme (ACE) may exhibit antioxidant properties, and that the antioxidant/prooxidant action of ACE inhibitors depends on the system studied in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0891-5849
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
729-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Antioxidant and prooxidant properties of captopril and enalapril.
pubmed:affiliation
Department of Physiology, Institute of Fundamental Sciences, Military Medical University, Lód?, Poland.
pubmed:publicationType
Journal Article, Comparative Study